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Panobinostat (CAS 404950-80-7)

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Synonym:LBH 589; (E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide
Application:An HDAC inhibitor
CAS Number:404950-80-7
Molecular Weight:349.43
Molecular Formula:C21H23N3O2
Refer to Certificate of Analysis for lot specific data (including water content).
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Panobinostat sc-208148 10 mg $186
Panobinostat (LBH589) is a HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).
Storage:Store at -20° C
Melting Point:>115 °C (dec.)
Boiling Point:608.15 °C (Predicted)
Density:~1.2 g/cm3 (Predicted)
Refractive Index:n20D 1.68 (Predicted)
IC50:Histone deacetylase: IC50 = 1.8 nM (Plasmodium falciparum); HDAC1: IC50 = 6.8 nM (human); COLO 205: IC50 = 18 nM (human); PC-3: IC50 = 24 nM (human); A2780: IC50 = 35 nM (human)
Ki Data:HDAC4: Ki= 0.6 nM (human); HDAC2: Ki= 0.65 nM (human); HDAC6: Ki= 0.7 nM (human); HDAC5: Ki= 0.7 nM (human); HDAC1: Ki= 1 nM (human)
pK Values:pKa: 8.71 (Predicted), pKb: 9.3 (Predicted)
Safety and Reference Information
PubChem CID:6918837
MDL Number:MFCD09833242
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
1. Catley, L., et al. 2006. Blood. 108: 3441-3449. PMID: 16728695
2. Fiskus, W., et al. 2006. Mol. Cancer Ther. 5: 3096-3104. PMID: 17172412
3. Scuto, A., et al. 2008. Blood. 111: 5093-5100. PMID: 18349321
4. Sasaki, D., et al. 2011. Haematologica. PMID: 21228036. PMID: 21228036
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