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Panobinostat (CAS 404950-80-7)

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Synonym:LBH 589; (E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide
Application:An HDAC inhibitor reported to inhibit human multiple myeloma cell lines
CAS Number:404950-80-7
Molecular Weight:349.43
Molecular Formula:C21H23N3O2
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Panobinostat sc-208148 10 mg $186
Panobinostat (LBH589) is a HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. The deacetylation of histones is associated with transcriptional silencing. Panobinostat was reported to inhibit several human myeloma cell lines with IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells.
Additional Images
Western blot analysis of Ac-Histone H4 acetylation in untreated (A) and Panobinostat (sc-208148) treated (B) A549 whole cell lysates. Antibodies tested include Ac-Histone H4 (Ser 1/Lys 5/Lys 8/Lys 12): sc-34263 (A,B). Note acetylation of Ac-Histone H4 in lane B.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).
Storage:Store at -20° C
Melting Point:>115° C (dec.)
Boiling Point:608.15° C (Predicted)
Refractive Index:n20D 1.68 (Predicted)
IC50:Histone deacetylase: IC50 = 1.8 nM (Plasmodium falciparum); HDAC1: IC50 = 6.8 nM (human); COLO 205: IC50 = 18 nM (human); PC-3: IC50 = 24 nM (human); A2780: IC50 = 35 nM (human)
Ki Data:HDAC4: Ki= 0.6 nM (human); HDAC2: Ki= 0.65 nM (human); HDAC6: Ki= 0.7 nM (human); HDAC5: Ki= 0.7 nM (human); HDAC1: Ki= 1 nM (human)
pK Values:pKa: 8.71 (Predicted), pKb: 9.3 (Predicted)
Safety and Reference Information
PubChem CID:6918837
MDL Number:MFCD09833242
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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1. Catley, L., et al. 2006. Blood. 108: 3441-3449. PMID: 16728695
2. Fiskus, W., et al. 2006. Mol. Cancer Ther. 5: 3096-3104. PMID: 17172412
3. Scuto, A., et al. 2008. Blood. 111: 5093-5100. PMID: 18349321
4. Sasaki, D., et al. 2011. Haematologica. PMID: 21228036. PMID: 21228036
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