santa cruz biotechnology, inc.
Laminin β-2 (H-300) Antibody: sc-20777
| Datasheet
rabbit polyclonal IgG, 200 µg/ml epitope corresponding to amino acids 1549-1798 mapping at the C-terminus of Laminin β-2 of human origin recommended for detection of Laminin β-2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
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Species
Gene Name
Gene ID
Chromosome Location
Isoform (mRNA) Accession #
Protein Accession #
OMIM™ Number
Human
LAMB2
3913
3p21.31
NM_002292
P55268
609049
Mouse
Lamb2
16779
9 F2
Q61292
N/A
Laminin β-2 Background Information The laminins comprise a growing family of disulfide-linked heterotrimers consisting of three genetically distinct polypeptide chains, designated å, ∫ and ©. A major component of the basal lamina, laminins play a crucial role in providing a scaffolding upon which tissues are assembled and which serves as a physical barrier separating specialized tissues. During embryogenesis and early development, cells migrate along basement membranes, which are required for the polarization of cells. The ∫-2 Laminin chain plays a role in melanoma spread, promoting tumor migration along the abluminal surface of a vessel, a phenomenon which has been termed extra-vascular migratory metastasis.
Laminin β-2 (H-300)
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Laminin β-2 (H-300): sc-20777. Western blot analysis of Laminin β-2 expression in HT-1080 (A) and HeLa (B) whole cell lysates.
Laminin β-2 (H-300): sc-20777. Western blot analysis of Laminin β-2 expression in HeLa (A), HT-1080 (B), LNCap (C) and DU 145 (D) whole cell lysates.
Laminin β-2 (H-300): sc-20777. Western blot analysis of Laminin β-2 expression in non-transfected:
sc-117752 (A) and mouse Laminin β-2 transfected:
sc-121282 (B) 293T whole cell lysates.
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