CYP1A1 Background Information P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds (1). Several P450 enzymes have been classified by sequence similarities as members of the CYP1A and CYP2A subfamilies (2). NADPH cytochrome P450 reductase is a microsomal enzyme responsible for the transfer of electrons from NADPH to cytochrome P450 enzymes during the P450 catalytic cycle (3,4). NADPH cytochrome P450 reductase is localized to the endoplasmic reticulum where it is also able to transfer electrons to heme oxygenase and cytochrome b5 (5,6). NADPH cytochrome P450 reductase is structurally related to two separate flavoprotein families, ferredoxin nucleotide reductase (FNR) and flavodoxin (7). Electron transfer of NADPH cytochrome P450 reductase requires the binding of two flavin cofactors, FAD and FMN, to the FNR and flavodoxin domains, respectively (8).
CYP1A1 (H-70) Product Citations
See how others have used CYP1A1 (H-70): sc-20772 antibody and or CYP1A1 (H-70) antibody conjugates.
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CYP1A1 (H-70)
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CYP1A1 (H-70) sc-20772. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic staining.
CYP1A1 (H-70): sc-20772. Western blot analysis of CYP1A1 expression in non-transfected: sc-117752 (A) and human CYP1A1 transfected: sc-114027 (B) 293T whole cell lysates.
CYP1A1 (H-70): sc-20772. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic and membrane staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
