Molecular structure of D-Eritadenine, CAS Number: 23918-98-1
D-Eritadenine (CAS 23918-98-1)
See product citations (6)
Alternate Names:
(2R,3R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxybutanoic acid
Application:
D-Eritadenine is a potent inhibitor of S-adenosyl-L-homocysteine hydrolase
CAS Number:
23918-98-1
Purity:
≥95%
Molecular Weight:
253.21
Molecular Formula:
C9H11N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
D-Eritadenine is a potent inhibitor of SAHH (S-adenosyl-L-homocysteine hydrolase). It is a hypocholesterolemic that is isolated from shiitake mushrooms and affects phospholipid and linoleicacid metabolisms, decreasing total cholesterol levels in plasma. It is a member of the 6-aminopurines class of organic compounds. This class consists of purines that contain an amino group at position 6. Purine is a bicyclic aromatic compound that is comprised of a pyrimidine ring fused to an imidazole ring. D-Eritadenine exists as a solid and is slightly soluble in water. It is also a weakly acidic compound, as indicated by its pKa value.
D-Eritadenine (CAS 23918-98-1) References
- Effects of dietary eritadenine on delta6-desaturase activity and fatty acid profiles of several lipids in rats fed different fats. | Shimada, Y., et al. 2002. Biosci Biotechnol Biochem. 66: 1605-9. PMID: 12224653
- Dietary eritadenine and ethanolamine depress fatty acid desaturase activities by increasing liver microsomal phosphatidylethanolamine in rats. | Shimada, Y., et al. 2003. J Nutr. 133: 758-65. PMID: 12612149
- Eritadenine-induced alterations of plasma lipoprotein lipid concentrations and phosphatidylcholine molecular species profile in rats fed cholesterol-free and cholesterol-enriched diets. | Shimada, Y., et al. 2003. Biosci Biotechnol Biochem. 67: 996-1006. PMID: 12834276
- Effects of dietary eritadenine on the liver microsomal Delta6-desaturase activity and its mRNA in rats. | Shimada, Y., et al. 2003. Biosci Biotechnol Biochem. 67: 1258-66. PMID: 12843651
- Probabilistic neural network model for the in silico evaluation of anti-HIV activity and mechanism of action. | Vilar, S., et al. 2006. J Med Chem. 49: 1118-24. PMID: 16451076
- Suppression of methionine-induced hyperhomocysteinemia by dietary eritadenine in rats. | Sekiya, A., et al. 2006. Biosci Biotechnol Biochem. 70: 1987-91. PMID: 16880595
- Dietary eritadenine suppresses guanidinoacetic Acid-induced hyperhomocysteinemia in rats. | Fukada, S., et al. 2006. J Nutr. 136: 2797-802. PMID: 17056803
- Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents. | Yamada, T., et al. 2007. Biochem Pharmacol. 73: 981-9. PMID: 17214973
- Quantification of the bioactive compound eritadenine in selected strains of shiitake mushroom (Lentinus edodes). | Enman, J., et al. 2007. J Agric Food Chem. 55: 1177-80. PMID: 17256958
- Production of the bioactive compound eritadenine by submerged cultivation of shiitake (Lentinus edodes) mycelia. | Enman, J., et al. 2008. J Agric Food Chem. 56: 2609-12. PMID: 18363329
- Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro. | Ctrnáctá, V., et al. 2010. Exp Parasitol. 126: 113-6. PMID: 20412798
- Lentinus edodes promotes fat removal in hypercholesterolemic mice. | Yang, H., et al. 2013. Exp Ther Med. 6: 1409-1413. PMID: 24255670
- Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. | Afrin, S., et al. 2016. J Agric Food Chem. 64: 2263-8. PMID: 26938194
- Hypocholesterolemic action of eritadenine is mediated by a modification of hepatic phospholipid metabolism in rats. | Sugiyama, K., et al. 1995. J Nutr. 125: 2134-44. PMID: 7643248
- Dietary eritadenine modifies plasma phosphatidylcholine molecular species profile in rats fed different types of fat. | Sugiyama, K., et al. 1997. J Nutr. 127: 593-9. PMID: 9109610
Inhibitor of:
SAHH, and VDAC1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-Eritadenine, 10 mg | sc-207632 | 10 mg | $228.00 |