Bendamustine Hydrochloride (CAS 3543-75-7)

5 3 (Based on popularity) 1

Application:	A nitrogen mustard purine analog alkylator
CAS Number:	3543-75-7
Molecular Weight:	394.72
Molecular Formula:	C₁₆H₂₁Cl₂N₃O₂ HCl

Ordering Information

Product Name	Catalog #	Unit	Price	Qty	Add
Bendamustine Hydrochloride	sc-207320	10 mg	$89
Bendamustine Hydrochloride	sc-207320A	100 mg	$250

This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

Description

Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe. Accordingly it has been indicated for use in treating proliferations and malignancies refractory to the effects of other DNA alkylators. Efficacy against chronic lymphocytic leukemia is particularly indicated with Bendamustine, presenting a potential intervention upon this notoriously variable and ubiquitous type of malignancy.

Technical Information

Appearance:	Pale Brown Crystals
Physical State:	Solid
Solubility:	Soluble in methanol, DMSO (≥79 mg/ml) at 25 °C, water (≥15 mg/ml) at 25 °C, and ethanol (≥17 mg/ml) at 25 °C.
Storage:	Store at -20° C
Melting Point:	149-151°C
Boiling Point:	585.2 °C at 760 mmHg (Predicted)
IC50:	SU-DHL-1 cell proliferation: IC₅₀ = 50 µM

Safety and Reference Information

Transport:	UN 3249, Class 6.1, Packing group III
RTECS:	DE1590000
PubChem CID:	77082
Merck Index:	14: 1032
MDL Number:	MFCD01658758
Beilstein Registry:	6031568
SMILES:	Cl.CN1C(CCCC(O)=O)=NC2=CC(=CC=C12)N(CCCl)CCCl

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Balfour, J.A. and Goa, K.L. 2001. Drugs. 61: 631-639. PMID: 11368287
2. Schwänen, C., et al. 2002. Leukemia. 16: 2096-2105. PMID: 12357363
3. Wendtner, C.M., et al. 2004. Semin. Hematol. 41: 224-233. PMID: 15269882
4. Keating, M.J., et al. 2008. Nat Rev Drug Discov. 7: 473-474. PMID: 18511926

SDS

Datasheet/SDS