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4,4'-Diisothiocyano-2,2'-stilbenedisulfonic Acid (CAS 53005-05-3)

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Synonym:DIDS
Application:An anion transport inhibitor
CAS Number:53005-05-3
Molecular Weight:454.52
Molecular Formula:C16H10N2O6S4
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Product NameCatalog #UnitPriceQtyAdd 
4,4'-Diisothiocyano-2,2'-stilbenedisulfonic Acid sc-206944 1 g $240
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Description
4,4'-Diisothiocyano-2,2'-stilbenedisulfonic Acid has been used to inhibit anion transport in various mammalian cell types. This compound has also been reported to act as a CD4 antagonist on JM cells and is able to block gp120, the envelope glycoprotein of HIV-1. Additionally, when added to HIV-1 infected cells, the compound was reported to block virus growth.
Technical Information
Appearance:Solid
Physical State:Solid
Storage:Store at -20° C
Melting Point:>400 °C
Density:1.54 g/cm3 (Predicted)
Refractive Index:n20D 1.69 (Predicted)
Fluoresence:λex 342 nm in water
IC50:gp120: IC50 > 10 µM; erythrocyte anion transport protein: IC50 = 31 µM; P2X purinoceptor 3: IC50 = 1 µM (human)
Safety and Reference Information
Transport:UN 2923, Class 8(6.1), Packing group III
PubChem CID:5281951
MDL Number:MFCD00065493
Beilstein Registry:5385887
SMILES:C1=CC(=C(C=C1N=C=S)S(=O)(=O)O)C=CC2=C(C=C(C=C2)N=C=S)S(=O)(=O)O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Cardin, A.D., et al. 1991. J. Biol. Chem. 266: 13355-13363. PMID: 2071607
2. Mayinger, P. and Meyer, D.I. 1993. EMBO J. 12: 659-666. PMID: 8440256
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