cyclin E Background Information Cyclins were first identified in invertebrates as proteins that oscillate dramatically through the cell cycle. These proteins have been well conserved through evolution and play a critical role in regulation of cell division. cyclin E, along with the three cyclin D proteins and cyclin C, has been shown to represent a putative G1 cyclin on the basis of its cyclic pattern of mRNA expression, with maximal levels being detected near the G1/S boundary. cyclin E has been found to be associated with the transcription factor E2F in a temporally regulated manner. The cyclin E/E2F complex is detected primarily during the G1 phase of the cell cycle and decreases as cells enter S phase. E2F is known to be a critical transcription factor for expression of several S phase specific proteins.
cyclin E (H-145) Product Citations
See how others have used cyclin E (H-145): sc-20684 antibody and or cyclin E (H-145) antibody conjugates.
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cyclin E (H-145)
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cyclin E (H-145): sc-20684. Western blot analysis of cyclin E expression in K-562 (A) and JEG-3 (B) whole cell lysates.
cyclin E (H-145): sc-20684. Western blot analysis of cyclin E expression in non-transfected: sc-117752 (A) and human cyclin E transfected: sc-170464 (B) 293T whole cell lysates.
