7-Acetoxy-4-methylcoumarin (CAS 2747-05-9)

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Synonym:	4-Methylumbelliferyl acetate
Application:	A fluorogenic substrate for carboxylesterase
CAS Number:	2747-05-9
Purity:	99%
Molecular Weight:	218.2
Molecular Formula:	C₁₂H₁₀O₄

Ordering Information

Product Name	Catalog #	Unit	Price	Qty	Add
7-Acetoxy-4-methylcoumarin	sc-206060	5 g	$100
7-Acetoxy-4-methylcoumarin	sc-206060A	25 g	$370

Description

7-Acetoxy-4-methylcoumarin is a fluorogenic substrate for carboxylesterase yielding a blue fluorescent solution upon cleavage. The compound has been used in aprotic media, a cell membrane environmental mimic, to study superoxide and related oxyl-radical reactions of model biological membranes dispersed in aqueous media. Due to the ability for AchE to cleave and activate 7-Acetoxy-4-methylcoumarin, the fluorogenic substrate has been used to study the AchE inhibitor Tacrine·HCl (sc-200172). The compound has also been isolated from Trigonella foenum graceum.

Technical Information

Appearance:	White powder
Physical State:	Solid
Solubility:	Soluble in chloroform, ethanol and acetone.
Storage:	Store at -20° C
Melting Point:	147-152 ºC

Safety and Reference Information

PubChem CID:	366
MDL Number:	MFCD00006865
EC Number:	220-386-6
Beilstein Registry:	189667
SMILES:	CC(=O)OC1=CC2=C(C=C1)C(C)=CC(=O)O2

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Berman, H.A. and Leonard, K. 1992. Mol. Pharmacol. 41: 412-418. PMID: 1538717
2. Frimer, A.A., et al. 1996. Free Radic. Biol. Med. 20: 843-852. PMID: 8728033
3. Bhardwaj, D.K., et al. 1977. Ind Journ Chem Sect. B-org. Chem. Med. Chem. 15: 94-95

SDS

Datasheet/SDS