PLC β2 (Q-15) Antibody: sc-206

PLC β2 Background Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC ∫1, PLC ∫2, PLC ∫3, PLC ∫4, PLC©1, PLC©2, PLC ∂1, PLC ∂2 and PLCe). PLC ∫s are the only PLC isforms that are regulated by G protein subunits and are activated by a heterotrimeric GTP-binding protein linked to various cell surface receptors. Two alternatively spliced forms (1181 and 1166 amino acids) of PLC ∫2 are generated in hematopoietic cells that differ in the carboxyl terminal sequence implicated in interaction of PLC ∫ enzymes with Gåq.The pleckstrin homology domain of PLC ∫2 is required for its targeting to the membrane and for substrate hydrolysis and its linker region exerts an inhibitory effect on basal PLC ∫2 activity. PLC ∫2 plays a major role in platelet activation and is mainly expressed in the periphery of the islet and acinar cells in rat pancreas.