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PD 153035 Hydrochloride (CAS 183322-45-4)

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Application:A potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase
CAS Number:183322-45-4
Molecular Weight:396.67
Molecular Formula:C16H14BrN3O2 HCl
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
PD 153035 Hydrochloride sc-205963 10 mg $125
PD 153035 Hydrochloride sc-205963A 50 mg $525
PD 153035 Hydrochloride is an extremely potent inhibitor of EGFR (epidermal growth factor receptor) tyrosine kinase (IC50 = 25 pM). Only inhibits other purified tyrosine kinases at micromolar or higher concentrations.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (10 mM) with gentle warming, water ( <1 mg/mL at 25° C), and ethanol ( <1 mg/mL at 25° C).
Storage:Store at room temperature
Boiling Point:472.1° C at 760 mmHg (Predicted)
Refractive Index:n20D 1.68 (Predicted)
IC50:EGFR: IC50 = 0.025 nM (human); ErbB-4: IC50 = 49 nM (human); Neu: IC50 = 143 nM (human); MCF7: IC50 = 1613 nM (human)
Ki Data:EGFR: Ki= 0.006 nM (human)
Safety and Reference Information
PubChem CID:11246488
MDL Number:MFCD01074805
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PD 153035 Hydrochloride Product Reviews

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1. Fry, D.W., et al. 1994. Science. 265: 1093-1095. PMID: 8066447
2. Bridges, A.J., et al. 1996. J. Med. Chem. 39: 267-276. PMID: 8568816
3. Bos, M., et al. 1997. Clin. Cancer Res. 3: 2099-2106. PMID: 9815602
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