NDSB-195 (CAS 160255-06-1)

Synonym:	Dimethylethylammonium Propane Sulfonate; 3-[ethyl(dimethyl)azaniumyl]propane-1-sulfonate
Application:	A nondetergent sulfobetaine used to solubilize proteins
CAS Number:	160255-06-1
Molecular Weight:	195.28
Molecular Formula:	C₇H₁₇NO₃S

Ordering Information

Product Name	Catalog #	Unit	Price	Qty	Add
NDSB-195	sc-205912	5 g	$115
NDSB-195	sc-205912A	25 g	$395

Description

NDSB-195 is a member of the class of nondetergent sulfobetaines. Unlike CHAPS and other zwittergents, NDSBs are nondenaturing even at 1 M concentrations. NDSBs have been used to improve the efficiency of solubilization of membrane proteins, to chromatographically purify halophilic proteins in low ionic strength buffers, to isolate nuclear proteins, and to crystallize proteins. They are zwitterionic over a wide pH range and do not absorb significantly in the near UV range. Reported to facilitate the renaturation of chemically and thermally denatured proteins and prevent protein aggregation. NDSBs can be easily removed by dialysis.

Technical Information

Appearance:	White
Physical State:	Solid
Solubility:	Soluble in water.
Storage:	Store at room temperature
Boiling Point:	478.51 °C at 760 mmHg (Predicted)

Safety and Reference Information

WGK Germany:	3
PubChem CID:	5221296
SMILES:	CC[N+](C)(C)CCCS(=O)(=O)[O-]

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Vuillard, L., et al. 1994. FEBS Lett. 353: 294-296. PMID: 7957878
2. Vuillard, L., et al. 1995. Anal. Biochem. 230: 290-294. PMID: 7826351
3. Vuillard, L., et al. 1995. Biochem. J. 305: 337-343. PMID: 7826351
4. Goldberg, M.E., et al. 1996. Fold. Des. 1: 21-27. PMID: 9079360

SDS

Datasheet/SDS