DAF-2 (CAS 205391-01-1)

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Application:	A sensitive and specific fluorescent indicator for the direct detection of nitric oxide (NO) in vitro
CAS Number:	205391-01-1
Molecular Weight:	362.3
Molecular Formula:	C₂₀H₁₄N₂O₅

Description

DAF-2 is a sensitive and specific fluorescent indicator for the direct detection of nitric oxide (NO) in vitro. In the presence of oxygen, the relatively non-fluorescent DAF-2 reacts rapidly with NO to yield the highly fluorescent triazolofluorescein compound. DAF-2 can detect NO under neutral conditions (detection limit = 5 nM).

Technical Information

Appearance:	Light yellow powder
Physical State:	Solid
Storage:	Store at -20° C
Fluoresence:	λex 495 nm, λem 515 nm in DMSO

Safety and Reference Information

PubChem CID:	10666340
SMILES:	C1=CC2=C(C=C1O)OC3=C(C24C5=CC(=C(C=C5C(=O)O4)N)N)C=CC(=C3)O

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Berkels, R., et al. 2000. Cell Calcium. 27: 281-286. PMID: 10859594
2. Kojima, H., et al. 1998. Anal. Chem. 70: 2446-2453. PMID: 9666719
3. Kojima, H., et al. 1998. Chem. Pharm. Bull. 46: 373-375. PMID: 9501473
4. Nakatsubo, N., et al. 1998. FEBS Lett. 427: 263-266. PMID: 9607324

SDS

Datasheet/SDS