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Ebastine (CAS 90729-43-4)

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Application:An antagonist of the histamine H1-receptor
CAS Number:90729-43-4
Molecular Weight:469.66
Molecular Formula:C32H39NO2
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Ebastine sc-205663 1 g $104
Ebastine sc-205663A 5 g $420
Ebastine is a non-sedating histamine H1 receptor antagonist that inhibits T cell migration as well and may find a use in the treatment of Th2-type autoimmune diseases.
Technical Information
Physical State:Solid
Solubility:Soluble in methanol, chloroform, and DMSO (>10 mg/ml). Insoluble in water.
Storage:Store at 4° C
Melting Point:84-87° C
Boiling Point:~596.3° C at 760 mmHg (Predicted)
Density:~1.1 g/cm3 (Predicted)
Refractive Index:n20D 1.59 (Predicted)
IC50:Histamine H1 Receptor: IC50 = 28.3 nM (human); SR-1A: IC50 = 47 nM (human); D2DR: IC50 = 61 nM (human); SR-2A: IC50 = 90.4 nM (human); Dopamine transporter: IC50 = 98.7 nM (human)
Ki Data:Histamine H1 Receptor: Ki= 3.29 nM (human); SR-2A: Ki= 25.8 nM (human); α2C-AR: Ki= 40.1 nM (human); D3DR: Ki= 41.3 nM (human); Dopamine transporter: Ki= 78.4 nM (human)
pK Values:pKb: 8.19 (Predicted)
Safety and Reference Information
WGK Germany:3
PubChem CID:3191
Merck Index:14: 3484
MDL Number:MFCD00865661
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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1. Roberts, D.J. 1996. Drugs. 52: 8-14. PMID: 8828021
2. Nori, M., et al. 2003. Clin. Exp. Allergy. 33: 1544-1554. PMID: 14616867
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