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Autophagy Inhibitor, 3-MA (CAS 5142-23-4)

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Synonym:3-methyladenine
Application:A multi-use inhibitor that protects cerebellar granule cells from apoptosis
CAS Number:5142-23-4
Purity:≥95%
Molecular Weight:149.15
Molecular Formula:C6H7N5
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Autophagy Inhibitor, 3-MA sc-205596 50 mg $89
Autophagy Inhibitor, 3-MA sc-205596A 500 mg $468
Description
Autophagy Inhibitor, 3-MA is a synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation. Autophagy Inhibitor, 3-MA is a PI 3-kinase p100 (class III PI 3-kinase inhibitor) that displays distinctly different properties from the PI 3-kinase inhibitors LY 294002 (sc-201426) and Wortmannin (sc-3505), in that treatment of cells with 3-MA results in specific redistribution of mannose 6-phosphate/insulin-like growth factor II receptor (MPR300), but does not cause the enlargement of late endosomal/lysosomal compartments. Autophagy Inhibitor, 3-MA is also an inhibitor of PI 3-kinase p110 γ.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (10 mg/ml), water (5 mg/ml), DMF (10 mg/ml), 95% ethanol, and 1N NaOH heating (30 mg/ml).
Storage:Store at 4° C
Melting Point:300 °C (lit.)(dec.)
Boiling Point:240 °C
Density:1.6 g/cm3
Refractive Index:n20D 1.81 (Predicted)
IC50:class III PI3K: IC50 = 4.5 mM
pK Values:pKb: 6.77 (Predicted)
Safety and Reference Information
WGK Germany:3
RTECS:AU6520000
PubChem CID:1673
MDL Number:MFCD00010531
EC Number:225-908-6
Beilstein Registry:146087
SMILES:CN1C=NC(=C2C1=NC=N2)N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Caro, L.H., et al. 1988. Eur. J. Biochem. 175: 325-329. PMID: 3402459
2. Eskelinen, E.L., et al. 2002. Traffic. 3: 878-893. PMID: 12453151
3. Beugnet, A., et al. 2003. Biochem. J. 372: 555-566. PMID: 12611592
4. Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316: 845-852. PMID: 15033478
5. Canu, N., et al. 2005. J. Neurochem. 92: 1228-1242. PMID: 15715672
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