Molecular structure of (S)-Equol, CAS Number: 531-95-3
(S)-Equol (CAS 531-95-3)
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Alternate Names:
(−)-Equol; 4′,7-Dihydroxyisoflavan; 4′,7-Isoflavandiol
Application:
(S)-Equol is a non-steroidal ERβ agonist
CAS Number:
531-95-3
Purity:
≥98%
Molecular Weight:
242.26
Molecular Formula:
C15H14O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(S)-Equol is a non-steroidal estrogen. The estrogen receptor (ER) agonist activity of the occurring (S)-enantiomer (EC50 = 85 and 65 nM for ERalpha and ERbeta, respectively) is similar to that of genistein but exceeds that of daidzein. (S)-Equol preferentially binds ERbeta (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERalpha (Ki = 6.41 nM). Also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.
(S)-Equol (CAS 531-95-3) References
- Equol is a novel anti-androgen that inhibits prostate growth and hormone feedback. | Lund, TD., et al. 2004. Biol Reprod. 70: 1188-95. PMID: 14681200
- Resveratrol, 4' Acetoxy Resveratrol, R-equol, Racemic Equol or S-equol as Cosmeceuticals to Improve Dermal Health. | Lephart, ED. 2017. Int J Mol Sci. 18: PMID: 28587197
- Effect of S-equol and Soy Isoflavones on Heart and Brain. | Sekikawa, A., et al. 2019. Curr Cardiol Rev. 15: 114-135. PMID: 30516108
- Isoflavone Supplements for Menopausal Women: A Systematic Review. | Chen, LR., et al. 2019. Nutrients. 11: PMID: 31689947
- S-Equol ameliorates insulin secretion failure through Chrebp/Txnip signaling via modulating PKA/PP2A activities. | Chen, K., et al. 2020. Nutr Metab (Lond). 17: 7. PMID: 31956333
- Role of S-Equol, Indoxyl Sulfate, and Trimethylamine N-Oxide on Vascular Function. | Matsumoto, T., et al. 2020. Am J Hypertens. 33: 793-803. PMID: 32300778
- S-EQUOL: a neuroprotective therapeutic for chronic neurocognitive impairments in pediatric HIV. | McLaurin, KA., et al. 2020. J Neurovirol. 26: 704-718. PMID: 32870477
- Utilization of Isoflavones in Soybeans for Women with Menopausal Syndrome: An Overview. | Chen, LR. and Chen, KH. 2021. Int J Mol Sci. 22: PMID: 33809928
- S-equol, a metabolite of dietary soy isoflavones, alleviates lipopolysaccharide-induced depressive-like behavior in mice by inhibiting neuroinflammation and enhancing synaptic plasticity. | Lu, C., et al. 2021. Food Funct. 12: 5770-5778. PMID: 34038497
- S-Equol mitigates motivational deficits and dysregulation associated with HIV-1. | McLaurin, KA., et al. 2021. Sci Rep. 11: 11870. PMID: 34088932
- (S)-Equol Is More Effective than (R)-Equol in Inhibiting Osteoclast Formation and Enhancing Osteoclast Apoptosis, and Reduces Estrogen Deficiency-Induced Bone Loss in Mice. | Tanaka, M., et al. 2022. J Nutr. 152: 1831-1842. PMID: 35675296
- An improved whole-cell biotransformation system for (S)-equol production. | Li, BJ., et al. 2022. Food Sci Nutr. 10: 2318-2324. PMID: 35844923
- Potential Protective Mechanisms of S-equol, a Metabolite of Soy Isoflavone by the Gut Microbiome, on Cognitive Decline and Dementia. | Sekikawa, A., et al. 2022. Int J Mol Sci. 23: PMID: 36233223
- High Titer of (S)-Equol Synthesis from Daidzein in Escherichia coli. | Deng, H., et al. 2022. ACS Synth Biol. 11: 4043-4053. PMID: 36282480
- S-Equol enhances osteoblastic bone formation and prevents bone loss through OPG/RANKL via the PI3K/Akt pathway in streptozotocin-induced diabetic rats. | Xu, Z., et al. 2022. Front Nutr. 9: 986192. PMID: 36337646
Inhibitor of:
17β-HSD4, and V1RG2.Activator of:
ER alpha, ER beta, GPR30, and ZP3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-Equol, 1 mg | sc-205502 | 1 mg | $33.00 | |||
(S)-Equol, 5 mg | sc-205502A | 5 mg | $147.00 | |||
(S)-Equol, 10 mg | sc-205502B | 10 mg | $255.00 | |||
(S)-Equol, 25 mg | sc-205502C | 25 mg | $571.00 |