Molecular structure of (−)-Cotinine, CAS Number: 486-56-6
(−)-Cotinine (CAS 486-56-6)
See product citations (3)
Alternate Names:
(S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
Application:
(−)-Cotinine is a major nicotine metabolite
CAS Number:
486-56-6
Purity:
≥98%
Molecular Weight:
176.22
Molecular Formula:
C10H12N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(−)-Cotinine, the primary metabolite of nicotine, is extensively studied in the context of its biomarker potential for nicotine exposure. Researchers utilize (−)-cotinine as an analytical tool in the assessment of smoke and tobacco use. In neuroscience research, (−)-cotinine is examined for its effects on cognitive function, where it is hypothesized to interact with nicotinic acetylcholine receptors, albeit with a lower affinity than nicotine. These interactions are a key focus in understanding the neurological pathways affected by chronic nicotine use. Furthermore, its stable structure makes (−)-cotinine an interesting candidate for developing new methods of bioanalysis and environmental monitoring techniques.
(−)-Cotinine (CAS 486-56-6) References
- The potential role of cotinine in the cognitive and neuroprotective actions of nicotine. | Buccafusco, JJ. and Terry, AV. 2003. Life Sci. 72: 2931-42. PMID: 12706481
- Development of an anti-cotinine vaccine to potentiate nicotine-based smoking cessation strategies. | Oliver, JL., et al. 2007. Vaccine. 25: 7354-62. PMID: 17870213
- Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice. | Echeverria, V., et al. 2011. J Alzheimers Dis. 24: 817-35. PMID: 21321389
- Determination of cotinine by LC-MS-MS with automated solid-phase extraction. | Dunlop, AJ., et al. 2014. J Chromatogr Sci. 52: 351-6. PMID: 23625914
- Good relationship between saliva cotinine kinetics and plasma cotinine kinetics after smoking one cigarette. | Yuki, D., et al. 2013. Regul Toxicol Pharmacol. 67: 240-5. PMID: 23933006
- Salivary cotinine levels as a biomarker for green tobacco sickness in dry tobacco production among Thai traditional tobacco farmers. | Saleeon, T., et al. 2016. Rocz Panstw Zakl Hig. 67: 121-30. PMID: 27289507
- Simultaneous determination of plasma nicotine and cotinine by UHPLC-MS/MS in C57BL/6 mice and its application in a pharmacokinetic study. | Liu, Y., et al. 2019. Biomed Chromatogr. 33: e4634. PMID: 31257625
- In vivo quantification and pharmacokinetic studies of cotinine in mice after smoke exposure by LC-MS/MS. | El Mubarak, MA., et al. 2020. Biomed Chromatogr. 34: e4752. PMID: 31756277
- Maternal Cotinine Levels and Red Blood Cell Folate Concentrations in the Periconceptual Period. | Yusuf, KK., et al. 2020. South Med J. 113: 156-163. PMID: 32239227
- Estimation and comparison of serum cotinine level among individuals with smoking and tobacco chewing habit. | Prabhakar, M., et al. 2020. Indian J Dent Res. 31: 531-536. PMID: 33107452
- Self-Administration of Cotinine in Wistar Rats: Comparisons to Nicotine. | Ding, ZM., et al. 2021. J Pharmacol Exp Ther. 376: 338-347. PMID: 33361363
- Cotinine Hydroxylase CotA Initiates Biodegradation of Wastewater Micropollutant Cotinine in Nocardioides sp. Strain JQ2195. | Zhao, L., et al. 2021. Appl Environ Microbiol. 87: e0092321. PMID: 34232707
- Melatonin prevents oocyte deterioration due to cotinine exposure in mice†. | Cheng, J., et al. 2022. Biol Reprod. 107: 635-649. PMID: 35191979
- Nicotine and cotinine quantification after a 4-week inhalation of electronic cigarette vapors in male and female mice using UPLC-MS/MS. | Alasmari, F., et al. 2022. Saudi Med J. 43: 678-686. PMID: 35830983
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(−)-Cotinine, 50 mg | sc-205267 | 50 mg | $71.00 | |||
(−)-Cotinine, 250 mg | sc-205267A | 250 mg | $117.00 | |||
(−)-Cotinine, 1 g | sc-205267B | 1 g | $270.00 |