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Vancomycin Hydrochloride (CAS 1404-93-9)

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Synonym:Vancocin HCl
Application:A glycopeptide cell wall disturbing antibiotic
CAS Number:1404-93-9
Molecular Weight:1485.71
Molecular Formula:C66H75Cl2N9O24•HCl
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Vancomycin Hydrochloride sc-204938 250 mg $55
Vancomycin Hydrochloride sc-204938A 1 g $149
Description
Vancomycin hydrochloride is a glycopeptide antibiotic that interferes with cell wall synthesis. Effective against Gram-positive bacteria.

For Vancomycin extracted from Streptomyces orientalis, please see sc-224363.
Technical Information
Appearance:Powder
Physical State:Solid
Solubility:Soluble in water (100 mg/ml), methanol, ethanol (<1 mg/ml at 25 °C), and DMSO (<1 mg/ml at 25 °C).
Storage:Store at 4° C
Melting Point:>175 °C (dec.)
Refractive Index:n20D 1.74 (Predicted)
IC50:mouse: EC5050 >100 µM; Human immunodeficiency virus 1: EC5050 >250 µM; Human immunodeficiency virus 2: EC5050 >250 µM; Enterococcus faecalis: IC50 = 0.06 ug/ml; Staphylococcus aureus: IC50 = 0.12 ug/ml
Ki Data:D-alanyl-D-alanine dipeptidase: Ki= 62 µM (Enterococcus faecium)
Safety and Reference Information
WGK Germany:2
RTECS:YW4380000
PubChem CID:14970
Merck Index:14: 9929
MDL Number:MFCD03613611
Beilstein Registry:3704657
SMILES:C[C@@H]1[C@@H]([C@](C[C@H](O1)O[C@H]2[C@@H]([C@H]([C@@H](O[C@@H]2OC3=C4C=C5C =C3OC6=C(C=C(C=C6)[C@H](C(C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8 )O)C9=C(C=C(C=C9[C@@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O )O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
Intravitreal injection of vancomycin in experimental staphylococcal endophthalmitis: P. Homer, et al.; Acta Ophthalmol. (Copenh) 53, 311 (1975) Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine: G.M. Sheldrick, et al.; Nature 271, 223 (1978) Hydrophobic interactions affect hydrogen bond strengths in complexes between peptides and vancomycin or ristocetin: M.P. Williamson & D.H. Williams; Eur. J. Biochem. 138, 345 (1984)
SDS (MSDS)
Certificate of Analysis

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