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Thiabendazole (CAS 148-79-8)

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Synonym:2-(4-Thiazolyl)-1H-benzimidazole
Application:A benzimidazole compound that acts as a fungicide
CAS Number:148-79-8
Purity:≥98%
Molecular Weight:201.25
Molecular Formula:C10H7N3S
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Thiabendazole sc-204913 10 g $40
Thiabendazole sc-204913A 100 g $103
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Description
Thiabendazole is a benzimidazole compound that acts as a fungicide and is reported to have aneugenic effects. Rat hepatocyte studies suggest that Thiabendazole mediates the induction of CYP1A1 and anuran Xenopus laevis studies demonstrate its ability to elevate the mRNA expression of hsp70 and IL-1β. Other studies indicate that Thiabendazole acts as a time dependent inhibitor of CYP1A2.
Technical Information
Physical State:Solid
Solubility:Soluble in ethanol (1 mg/ml), DMF (50 mg/ml), chlorinated hydrocarbons (slightly), DMSO (40 mg/ml), and water (<1 mg/ml).
Storage:Store at 4° C
Melting Point:301 °C (lit.)
Boiling Point:~446.0 °C at 760 mmHg (Predicted)
Density:~1.4 g/cm3 (Predicted)
Refractive Index:n20D 1.74 (Predicted)
IC50:Methionine aminopeptidase: IC50 = 472 nM (Escherichia coli K-12); CYP1A2: IC50 = 800 nM (human); Human immunodeficiency virus type 1 reverse transcriptase: IC50 = 14.6 µM; MetAP-2: IC50 = 44.7 µM (human); MetAP-1: IC50 = 47.8 µM (human)
Ki Data:CYP2C9: Ki= 245 nM (human)
pK Values:pKa: 10.53 (Predicted), pKb: 3.4 (Predicted)
Safety and Reference Information
Transport:UN 3077, Class 9, Packing group III
WGK Germany:2
RTECS:DE0700000
PubChem CID:5430
Merck Index:14: 9298
MDL Number:MFCD00005587
EC Number:205-725-8
Beilstein Registry:611403
SMILES:C1=CC=C2C(=C1)NC(=N2)C3=CSC=N3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Lemaire, G., et al. 2004. Life Sci. 74: 2265-2278. PMID: 14987951
2. Thelingwani, R.S., et al. 2009. Drug Metab. Dispos. 37: 1286-1294. PMID: 19299526
3. Santovito, A., et al. 2010. Arch Toxicol. [Epub ahead of print]. PMID: 20938648
4. Martini, F., et al. 2010. Environ. Toxicol. Chem. 29: 2536-2543. PMID: 20886500
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