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Phenylbutazone (CAS 50-33-9)

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Application:An inhibitor of Cox
CAS Number:50-33-9
Molecular Weight:308.38
Molecular Formula:C19H20N2O2
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Phenylbutazone sc-204843 5 g $30
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Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.
Technical Information
Physical State:Solid
Solubility:Soluble in water (1 mg/ml at 25 °C), ethanol (62 mg/ml at 25 °C), methanol, DMSO (62 mg/ml at 25 °C), and DMF (25 mg/ml).
Storage:Store at room temperature
Melting Point:106-108 °C (lit.)
Boiling Point:~424.9 °C at 760 mmHg (Predicted)
Density:~1.2 g/cm3 (Predicted)
Refractive Index:n20D 1.59 (Predicted)
IC50:Cox-1: IC50 = 3 µM (human); Cyclooxygenase-2: IC50 = 3.79 µM (Canis lupus familiaris); PGH synthase : IC50 = 10 µM; Plasmodium falciparum 3D7: IC50 = 10 µM; Plasmodium falciparum D10: IC50 = 12.59 µM
Ki Data:CYP2C9: Ki= 19 µM (human); OAT3: Ki= 34.7 µM (human); AZT glucuronidation: Ki= 1.4 mM (human); Codeine glucuronidation: Ki= 1.7 mM
pK Values:pKa: 4.64 (Predicted)
Safety and Reference Information
Transport:UN 2811, Class 6.1, Packing group III
WGK Germany:3
PubChem CID:4781
Merck Index:14: 7277
MDL Number:MFCD00005500
EC Number:200-029-0
Beilstein Registry:290080
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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1. Takahashi, M., et al. 1990. Carcinogenesis. 11: 393-395. PMID: 2311181
2. Hixson, L.J., et al. 1994. Cancer Epidemiol. Biomarkers Prev. 3: 433-438. PMID: 7920212
3. Rainsford, K.D. 2007. Subcell. Biochem. 42: 3-27. PMID: 17612044
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