Phenylbutazone (CAS 50-33-9)

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Application:	An inhibitor of Cox
CAS Number:	50-33-9
Purity:	≥99%
Molecular Weight:	308.38
Molecular Formula:	C₁₉H₂₀N₂O₂

This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

Description

Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.

Technical Information

Appearance:	White to off-white powder.
Physical State:	Solid
Solubility:	Soluble in water, 100% ethanol (50mg/ml), DMSO (25mg/ml) or dimethyl formamide (25mg/ml).
Storage:	Store at room temperature

Safety and Reference Information

Transport:	UN 2811, Class 6.1, Packing group III
PubChem CID:	4781
SMILES:	CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Takahashi, M., et al. 1990. Carcinogenesis. 11: 393-395. PMID: 2311181
2. Hixson, L.J., et al. 1994. Cancer Epidemiol. Biomarkers Prev. 3: 433-438. PMID: 7920212
3. Rainsford, K.D. 2007. Subcell. Biochem. 42: 3-27. PMID: 17612044

SDS

Datasheet/SDS