NFκB Activation Inhibitor III (CAS 380623-76-7)

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Application:	A TNF-alpha-stimulated NF kappa B activation inhibitor
CAS Number:	380623-76-7
Molecular Weight:	328.7
Molecular Formula:	C₁₀H₅ClN₄O₅S

Description

NF-κB Activation Inhibitor III is a thiazoloamide compound experimentally shown to inhibit TNF-α-stimulated NF-κB activation and MMP-9 in HT1080 upregulation. This upregulation corresponds to a concomitant inhibition of TNF-α-dependent cellular invasion. This compound has not been shown to affect the TNF-α-induced AP-1, occurring downstream of p38 activation.

Technical Information

Appearance:	Light yellow amorphous solid
Physical State:	Solid
Solubility:	Soluble in DMSO.
Storage:	Store at 4° C

Safety and Reference Information

SMILES:

O=C(Nc1ncc(s1)[N+](=O)[O-])c1ccc([N+](=O)[O-])c(Cl)c1

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Lee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun. 336: 716-722. PMID: 16140265

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SDS

Datasheet/SDS