Letrozole (CAS 112809-51-5)

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Application:	A CYP19 (aromatase) inhibitor
CAS Number:	112809-51-5
Purity:	>98%
Molecular Weight:	285.30
Molecular Formula:	C₁₇H₁₁N₅

Ordering Information

Product Name	Catalog #	Unit	Price	Qty	Add
Letrozole	sc-204791	25 mg	$77
Letrozole	sc-204791A	50 mg	$135

This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

Description

Letrozole acts as a nonsteroidal CYP19 (aromatase) inhibitor. It is also known to inhibit estradiol production in vitro in hamster ovarian tissue that is LH-stimulated. Letrozole has not been shown to have a significant effect on progesterone production up to 350 M. Letrazole has been shown to inhibit aldosterone production in vitro in rat adrenal tissue stimulated by ACTH. No significant effect has been seen on corticosterone production at 350 M. Letrozole has no effect on corticosterone or aldoterone levels in vivo in ACTH-treated rats.

Technical Information

Appearance:	White to almost white crystalline powder
Physical State:	Solid
Solubility:	Soluble in dichloromethane
Storage:	Store at room temperature

Safety and Reference Information

Transport:	UN 3077, Class 9, Packing group III
PubChem CID:	3902
SMILES:	C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

Ingle JN. Oncology (Huntingt). 15:28-34 (2001). Bhatnagar AS, Hausler A, Schieweck K et al. J Steroid Biochem Mol Biol. 37:1021-7 (1990). Brodie AM. J Steroid Biochem Mol Biol. 49:281-7 (1994).

SDS

Datasheet/SDS