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Fenofibrate (CAS 49562-28-9)

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Synonym:Procetofen; Trilipix
Application:A hypolipidemic PPARα agonist
CAS Number:49562-28-9
Molecular Weight:360.83
Molecular Formula:C20H21ClO4
Refer to Certificate of Analysis for lot specific data (including water content).
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Fenofibrate sc-204751 5 g $34
Fenofibrate is a hypolipidemic compound which acts as a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 18 μM for mouse and EC50 = 30 μM for human). Fenofibrate also binds to PPARγ with at least 10-fold less affinity, and is inactive at PPARδ at concentrations up to 100 μM.
Technical Information
Physical State:Solid
Solubility:Soluble in acetone, ether, DMSO (15 mg/ml), DMF (30 mg/ml), ethanol (1 mg/ml), methanol (slightly soluble), benzene, chloroform, DMF:PBS (1:3 pH 7.2) (0.25 mg/ml), ethyl acetate, acetonitrile, and hexane. Insoluble in water.
Storage:Store at -20° C
Melting Point:79-83° C
Boiling Point:469.77° C at 760 mmHg (Predicted)
Density:1.18 g/cm3 (Predicted)
Refractive Index:n20D 1.55 (Predicted)
IC50:Dopamine transporter: IC50 = 8.63 µM (human); Acetylcholinesterase: IC50 = 15.55 µM (human); LoVo: IC50 = 13.2 µM (human); Serotonin 2a receptor: IC50 = 2.12 µM (human); ADORA3 protein: IC50 = 5.7 µM (human); Peroxisome proliferator-activated receptor alpha: IC50 = 1 µM (human); PPARα: EC5050 = 18 µM (murine); PPARα: EC5050 = 30 µM (human)
Ki Data:ADORA3 protein: Ki= 3.22 µM (human); Serotonin 2c receptor: Ki= 1.24 µM (human); Fatty acid-binding protein, liver: Ki= 0.41 µM (rat)
Safety and Reference Information
WGK Germany:3
PubChem CID:3339
Merck Index:14: 3978
MDL Number:MFCD00133314
EC Number:256-376-3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Inhibition of membrane-bound hepatic 3 hydroxy-3 methyl glutaryl CoA reductase as the consequence of altered membrane fluidity: E. Wulfert, et al.; Artery 9, 120 (1981) Fenofibrate protects lipoproteins from lipid peroxidation: synergistic interaction with alpha-tocopherol: E. Chaput, et al.; Lipids 34, 497 (1999) Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study: S. Pierno, et al.; Br. J. Pharmacol. 149, 909 (2006) In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer: S.A. Saidi, et al.; Mol. Cancer 5, 13 (2006) PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition: D. Panigrahy, et al.; PNAS 105, 985 (2008)
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