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Doxycycline Hyclate (CAS 24390-14-5)

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Synonym:Doxycycline hydrochloride hemiethanolate hemihydrate; Atridox
Application:An antimicrobial tetracycline that acts as an inhibitor of metalloproteinases (MMPs)
CAS Number:24390-14-5
Purity:≥98%
Molecular Weight:512.94
Molecular Formula:C22H24N2O8•HCl•1/2H2O•1/2C2H6O
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Product NameCatalog #UnitPriceQtyAdd 
Doxycycline Hyclate sc-204734 1 g $30
Doxycycline Hyclate sc-204734A 5 g $65
Description
Doxycycline Hyclate, also called Doxycycline is an antimicrobial tetracycline that acts as an inhibitor of a wide range of matrix metalloproteinases (MMPs). This product has been observed to significantly decrease the levels and activity of metalloproteinase-9 (MMP-9) in corneal erosion studies. Rheumatoid arthriitis studies indicate that Doxycycline can block the degradation of type II collagen, and not type I collagen, as well as downregulate the expression levels and activity of MMP-8. Reports suggest that Doxycycline blocks collagen activity and in smooth muscle studies increases smooth muscle cell adhesion, and changes the reorganization of fibrillar collagen matrices and cell migration. Additionally, Doxycycline has been observed to alter the expression of apicoplast genes in Plasmodium falciparum, and inhibit tissue formation.
Technical Information
Appearance:Yellow crystalline solid.
Physical State:Solid
Solubility:Soluble in water (50mg/ml).
Storage:Store at -20° C
Safety and Reference Information
WGK Germany:3
PubChem CID:54732805
MDL Number:MFCD07357237
Beilstein Registry:5702728
SMILES:CCO.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=C(C(=O)[C@]3(C(=O)C2=C(C4=C1C=CC=C4 O)O)O)C(=O)N)O)N(C)C)O.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=C(C(=O)[C@]3(C(= O)C2=C(C4=C1C=CC=C4O)O)O)C(=O)N)O)N(C)C)O.O.Cl.Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Takafuji, E.T., et al. 1984. N. Engl. J. Med. 310: 497-500. PMID: 6363930
2. Suomalainen, K., et al. 1992. Antimicrob. Agents Chemother. 36: 227-229. PMID: 1317148
3. Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272: 31504-31509. PMID: 9395486
4. Dursun, D., et al. 2001. Am. J. Ophthalmol. 132: 8-13. PMID: 11438047
5. Lamparter, S., et al. 2002. J. Lab. Clin. Med. 139: 295-302. PMID: 12032490
6. Franco, C., et al. 2006. Am. J. Pathol. 168: 1697-1709. PMID: 16651635
7. Dahl, E.L., et al. 2006. Antimicrob. Agents Chemother. 50: 3124-3131. PMID: 16940111
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