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Ciprofibrate (CAS 52214-84-3)

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Application:A hypolipidemic agonist of PPARα
CAS Number:52214-84-3
Molecular Weight:289.2
Molecular Formula:C13H14Cl2O3
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Ciprofibrate sc-204689 25 mg $50
Ciprofibrate sc-204689A 100 mg $163
Ciprofibrate is a hypolipidemic compound that can induce proliferation of peroxisomes in liver cells of rats. Known to be a PPARα (peroxisome proliferator-activated receptor α) agonist.
Technical Information
Physical State:Solid
Solubility:Soluble in water (<1 mg/ml at 25° C), chloroform (miscible), acetone (miscible), ethanol (58 mg/ml at 25° C), and DMSO (58 mg/ml at 25° C).
Storage:Store at -20° C
Melting Point:114-116° C
Boiling Point:~424.9° C at 760 mmHg (Predicted)
Density:~1.4 g/cm3 (Predicted)
Refractive Index:n20D 1.58 (Predicted)
IC50:PPARα: EC5050 = 0.9 µM (human); PPARα: EC5050 >10 µM (rat)
pK Values:pKa: 3.31 (Predicted)
Safety and Reference Information
WGK Germany:3
PubChem CID:2763
Merck Index:14: 2313
MDL Number:MFCD00467135
EC Number:257-744-6
Beilstein Registry:1984981
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures: V. Goll, et al.; Toxicol. Appl. Pharmacol. 160, 21 (1999) Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate: P. Passilly, et al.; Biochem. Pharmacol. 58, 1001 (1999) Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate: M.C. Clemencet, et al.; Cancer Lett. 222, 217 (2005) P450 CYP2C epoxygenase and CYP4A w-hydroxylase mediate ciprofibrate-induced PPARa-dependent peroxisomal proliferation: A. Gatica, et al.; J. Lipid Res. 48, 924 (2007) Lalwani ND, Reddy MK, Qureshi SA et al. Hum Toxicol. 2:27-48 (1983). Clemencet MC, Muzio G, Trombetta A et al. Cancer Lett. 222:217-226 (2005).
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