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Ciprofibrate (CAS 52214-84-3)

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Application:A hypolipidemic agonist of PPARα
CAS Number:52214-84-3
Purity:≥98%
Molecular Weight:289.2
Molecular Formula:C13H14Cl2O3
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Ciprofibrate sc-204689 25 mg $50
Ciprofibrate sc-204689A 100 mg $163
Description
Ciprofibrate is a hypolipidemic compound that can induce proliferation of peroxisomes in liver cells of rats. Known to be a PPARα (peroxisome proliferator-activated receptor α) agonist.
Technical Information
Appearance:Powder
Physical State:Solid
Solubility:Soluble in water (<1 mg/ml at 25 °C), chloroform (miscible), acetone (miscible), ethanol (58 mg/ml at 25 °C), and DMSO (58 mg/ml at 25 °C).
Storage:Store at -20° C
Melting Point:114-116 °C
Boiling Point:~424.9 °C at 760 mmHg (Predicted)
Density:~1.4 g/cm3 (Predicted)
Refractive Index:n20D 1.58 (Predicted)
IC50:PPARα: EC5050 = 0.9 µM (human); PPARα: EC5050 >10 µM (rat)
pK Values:pKa: 3.31 (Predicted)
Safety and Reference Information
WGK Germany:3
RTECS:UF0880000
PubChem CID:2763
Merck Index:14: 2313
MDL Number:MFCD00467135
EC Number:257-744-6
Beilstein Registry:1984981
SMILES:CC(C)(OC1=CC=C(C=C1)C1CC1(Cl)Cl)C(O)=O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures: V. Goll, et al.; Toxicol. Appl. Pharmacol. 160, 21 (1999) Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate: P. Passilly, et al.; Biochem. Pharmacol. 58, 1001 (1999) Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate: M.C. Clemencet, et al.; Cancer Lett. 222, 217 (2005) P450 CYP2C epoxygenase and CYP4A w-hydroxylase mediate ciprofibrate-induced PPARa-dependent peroxisomal proliferation: A. Gatica, et al.; J. Lipid Res. 48, 924 (2007) Lalwani ND, Reddy MK, Qureshi SA et al. Hum Toxicol. 2:27-48 (1983). Clemencet MC, Muzio G, Trombetta A et al. Cancer Lett. 222:217-226 (2005).
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