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Rab GDI α (N-20) Antibody: sc-20447 |
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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of Rab GDI α of human origin
- recommended for detection Rab GDIα of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-20447 P
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Rab GDI α Background Information
Rab proteins, a family of Ras-related small GTP-binding proteins, play a key role in regulating intracellular vesicle trafficking (1–3). Rab GDP dissociation inhibitor (Rab GDI or GDI2) forms a soluble complex with Rab proteins and thereby prevents the exchange of GDP for GTP (1–3). In mammals, there exist two major isoforms, Rab GDI å (also known as XAP-4) and Rab GDI ∫ (1,4). While the mammalian Rab GDI ∫-genes are ubiquitously expressed, the Rab GDI å genes are predominantly brain-specific (1). Since it is expressed predominantly in neural and sensory tissues, Rab GDI a may serve a specific function in neural signal transmission (5). The gene sequences for the Rab GDI proteins are extremely conserved in evolution, with substantial homology preserved across three eukaryotic kingdoms (5). |
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Rab GDI α (N-20)
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Rab GDI α (N-20): sc-20447. Western blot analysis of Rab GDI α expression in non-transfected: sc-110760 (A) and human Rab GDI α transfected: sc-110992 (B) 293 whole cell lysates. Rab GDI α (N-20): sc-20447. Western blot analysis of Rab GDI α expression in HeLa whole cell lysate.
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