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WHI-P180, Hydrochloride (CAS 211555-08-7)

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Application:An IgE-mediated mast cell response inhibitor
CAS Number:211555-08-7
Molecular Weight:333.77
Molecular Formula:C16H15N3O3 HCl
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
WHI-P180, Hydrochloride sc-204396 500 µg $117
WHI-P180, Hydrochloride sc-204396A 1 mg $298
Description
WHI-P180, Hydrochloride is a potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. WHI-P180, Hydrochloride also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 μM) by blocking the ATP site.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (50 mg/ml).
Storage:Store at 4° C
Refractive Index:n20D 1.69 (Predicted)
IC50:PI 3-kinase p85α: IC50 = 2 nM (human); Flt-1: IC50 = 200 nM (human); Flk-1: IC50 = 50 nM (human); Cdk2: IC50 = 1 µM (human); Flg: IC50 = 11 µM (human)
Safety and Reference Information
PubChem CID:5687
MDL Number:MFCD09026915
SMILES:COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)O)OC
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
Shewchuk, L., et al. 2000. J. Med. Chem. 43, 133. Chen, C.L., et al. 1999. Pharm. Res. 16, 117.
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Certificate of Analysis

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