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TCB-2 (CAS 912342-28-0)

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Synonym:(4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide
Application:A high affinity SR-2A agonist
CAS Number:912342-28-0
Purity:≥99%
Molecular Weight:353.05
Molecular Formula:C11H14BrNO2 HBr
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
TCB-2 sc-204325 10 mg $179
TCB-2 sc-204325A 50 mg $739
Not available for sale outside of the United States.
Description
TCB-2 is a high affinity SR-2A agonist (Ki values are 0.73 and 0.75 nM for rat and human receptors, respectively). TCB-2 potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat SR-2A (EC50 = 36 nM).
Technical Information
Appearance:Crystalline
Physical State:Solid
Solubility:Solubility: Soluble to 25 mM in Water, to 100 mM in DMSO, and to 10 mM in Ethanol
Storage:Desiccate at 4° C
Safety and Reference Information
PubChem CID:16086372
SMILES:COC1=CC(=C(C2=C1C(C2)CN)OC)Br.Br
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
McLean et al (2006) 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists. J.Med.Chem. 49 5794.
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Certificate of Analysis

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