Date published: 2025-12-23

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Spironolactone (CAS 52-01-7)

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Application:
Spironolactone is a lactone for proteomic research
CAS Number:
52-01-7
Molecular Weight:
416.57
Molecular Formula:
C24H32O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Spironolactone is a competitive MCR (mineralocorticoid receptor) antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis. Spironolactone is an inhibitor of AR.


Spironolactone (CAS 52-01-7) References

  1. A comparison of the aldosterone-blocking agents eplerenone and spironolactone.  |  Struthers, A., et al. 2008. Clin Cardiol. 31: 153-8. PMID: 18404673
  2. Spironolactone interference in the immunoassay of androstenedione.  |  Honour, JW., et al. 2010. Ann Clin Biochem. 47: 564-6. PMID: 20926464
  3. Spironolactone, eplerenone and the new aldosterone blockers in endocrine and primary hypertension.  |  Colussi, G., et al. 2013. J Hypertens. 31: 3-15. PMID: 23011526
  4. Evolving strategies for the use of spironolactone in cardiovascular disease.  |  Jolobe, OM. 2013. Eur J Intern Med. 24: 303-9. PMID: 23245930
  5. Converging indications of aldosterone antagonists (spironolactone and eplerenone): a narrative review of safety profiles.  |  Danjuma, MI., et al. 2014. Curr Hypertens Rep. 16: 414. PMID: 24407447
  6. Mineralocorticoid receptor antagonists, a class beyond spironolactone--Focus on the special pharmacologic properties of eplerenone.  |  Seferovic, PM., et al. 2015. Int J Cardiol. 200: 3-7. PMID: 26404746
  7. Safety profile of mineralocorticoid receptor antagonists: Spironolactone and eplerenone.  |  Lainscak, M., et al. 2015. Int J Cardiol. 200: 25-9. PMID: 26404748
  8. Spironolactone Effect in Hepatic Ischemia/Reperfusion Injury in Wistar Rats.  |  Pérez, JC., et al. 2016. Oxid Med Cell Longev. 2016: 3196431. PMID: 26798418
  9. Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives.  |  Larik, FA., et al. 2017. Steroids. 118: 76-92. PMID: 28041953
  10. Addition of spironolactone in patients with resistant hypertension: A meta-analysis of randomized controlled trials.  |  Liu, L., et al. 2017. Clin Exp Hypertens. 39: 257-263. PMID: 28448185
  11. Evaluation of the safety and tolerability of spironolactone in patients with heart failure and chronic kidney disease.  |  Buckallew, AR., et al. 2021. Eur J Clin Pharmacol. 77: 955-960. PMID: 33449127
  12. Spironolactone effect on the blood pressure of patients at risk of developing heart failure: an analysis from the HOMAGE trial.  |  Ferreira, JP., et al. 2022. Eur Heart J Cardiovasc Pharmacother. 8: 149-156. PMID: 33822033
  13. Spironolactone affects cardiovascular and craniofacial development in zebrafish embryos (Danio rerio).  |  Petty, HJ., et al. 2022. Environ Toxicol Pharmacol. 92: 103848. PMID: 35288337

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Spironolactone, 50 mg

sc-204294
50 mg
$107.00