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PTP Inhibitor I (CAS 2491-38-5)

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Synonym:4-Hydroxyphenacyl bromide
Application:A potent covalent inhibitor of protein tyrosine phosphatases SHP-1 and PTPIB
CAS Number:2491-38-5
Purity:≥95%
Molecular Weight:215.1
Molecular Formula:C8H7BrO2
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
PTP Inhibitor I sc-204220 10 mg $210
PTP Inhibitor I sc-204220A 100 mg $400
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Description
PTP Inhibitor I is a potent covalent inhibitor of protein tyrosine phosphatases. The compound is found to be cell-permeable and to specifically inhibit SHP-1 and PTPIB (Protein tyrosine phosphatase 1B). It has been observed in human ovarian cancer cells when SHP-1 is inhibited anti-tumor activity is induced. Inhibition of PTPIB has been observed to upregulate the insulin receptor signal transduction pathway. Although PTP inhibitors would prove useful for elucidating PTP signal transduction, selective active site binding has been shown to be difficult to achieve. PTP inhibitor I is utilized in laboratories as a derivatization reagent for High Performance Liquid Chromatography analysis of carboxylic acids.
Technical Information
Appearance:White powder
Physical State:Solid
Solubility:Soluble in chloroform, DMSO (200 mg/ml), methanol, and water (partly miscible).
Storage:Store at -80° C
Boiling Point:338.69 °C at 760 mmHg (Predicted)
Density:1.62 g/cm3 (Predicted)
Refractive Index:n20D 1.61 (Predicted)
Safety and Reference Information
Transport:UN 2928, Class 6.1, Packing group II
PubChem CID:4964
MDL Number:MFCD00072424
EC Number:219-655-0
SMILES:OC1=CC=C(C=C1)C(=O)CBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Jensen, C.D., et al. 2003. Am. J. Contact Dermatitis. 14: 41-43. PMID: 14744423
2. Bishop, A.C., et al. 2007. Methods. 42: 278-288. PMID: 17532515
3. Inada, S., et al. 2007. Mol. Cell. Endocrinol. 271: 64-70. PMID: 17509747
4. Caron, D., et al. 2008. Cancer Lett. 262: 265-275. PMID: 18234419
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