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PNU 142633 (CAS 187665-65-2)

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Application:A high affinity SR-1D agonist
CAS Number:187665-65-2
Molecular Weight:422.53
Molecular Formula:C24H30N4O3
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
PNU 142633 sc-204204 10 mg $205
PNU 142633 is a very selective, high affinity SR-1D agonist (Ki values are 6 and > 18000 nM at human SR-1D and SR-1B, respectively). PNU 142633 blocks neurogenic plasma protein extravasation and inhibits sympathetically-induced tachycardic responses in vivo.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (100 mM), and ethanol (20 mM).
Storage:Store at 4° C
Melting Point:287.06 °C (Predicted)
Boiling Point:652.51 °C at 760 mmHg (Predicted)
Density:1.20 g/cm3 (Predicted)
Refractive Index:n20D 1.60 (Predicted)
Ki Data:SR-1D: Ki= 4.6 nM (human)
pK Values:pKb: 7.27 (Predicted)
Safety and Reference Information
PubChem CID:9845148
MDL Number:MFCD10687093
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PNU 142633 Product Reviews

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Roon et al (1999) Bovine isolated middle cerebral artery contractions to antimigraine drugs. Naunyn-Schmied.Arch.Pharmacol. 360 591. McCall et al (2002) Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-142633. Cephalalgia 22 799. Sanchez-Lopez et al (2003) Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors. Br.J.Pharmacol. 140 725.
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