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PNU 142633 (CAS 187665-65-2)

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Application:A high affinity SR-1D agonist
CAS Number:187665-65-2
Molecular Weight:422.53
Molecular Formula:C24H30N4O3
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Product NameCatalog #UnitPriceQtyAdd 
PNU 142633 sc-204204 10 mg $189
Description
PNU 142633 is a very selective, high affinity SR-1D agonist (Ki values are 6 and > 18000 nM at human SR-1D and SR-1B, respectively). PNU 142633 blocks neurogenic plasma protein extravasation and inhibits sympathetically-induced tachycardic responses in vivo.
Technical Information
Physical State:Solid
Solubility:Soluble to 100 mM in DMSO and to 20 mM in Ethanol
Storage:Store at 4° C
Safety and Reference Information
PubChem CID:9845148
SMILES:CNC(=O)C1=CC2=C(C=C1)[C@@H](OCC2)CCN3CCN(CC3)C4=CC=C(C=C4)C(=O)N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
Roon et al (1999) Bovine isolated middle cerebral artery contractions to antimigraine drugs. Naunyn-Schmied.Arch.Pharmacol. 360 591. McCall et al (2002) Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-142633. Cephalalgia 22 799. Sanchez-Lopez et al (2003) Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors. Br.J.Pharmacol. 140 725.
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