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Gedunin (CAS 2753-30-2)

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Synonym:(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12­aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b­,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethylox­ireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
Application:An Hsp90 inhibitor
CAS Number:2753-30-2
Purity:>98%
Molecular Weight:482.57
Molecular Formula:C28H34O7
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Gedunin sc-203967 10 mg $169
Description
Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Gedunin exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).
Technical Information
Appearance:Colorless crystals
Physical State:Solid
Solubility:Soluble to 100 mM in DMSO and to 10 mM in Ethanol
Storage:Store at 4° C
Safety and Reference Information
RTECS:LK9275200
PubChem CID:5701985
SMILES:CC(=O)O[C@@H]1CC2[C@](C=CC(=O)C2(C)C)(C3[C@@]1([C@]45[C@H](O4)C(=O)O[C@H]([C @@]5(CC3)C)C6=COC=C6)C)C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
Uddin et al (2007) Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytother.Res. 21 757. Brandt et al (2008) Gedunin, a novel Hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. J.Med.Chem. 51 6495. Lee et al (2008) Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). Phytomedicine 15 533.
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