Date published: 2025-12-22

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Dermatan Sulfate (CAS 54328-33-5)

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Alternate Names:
Chrondroitin Sulfate B; Iduronic Acid-β-1,4-N-acetyl-D-galactosamine
Application:
Dermatan Sulfate is a mucopolysaccharide acts as a potent mediator of FGF-2 responsiveness
CAS Number:
54328-33-5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dermatan sulfate (Chrondroitin Sulfate B) is a mucopolysaccharide containing iduronic acid. Dermatan sulfate is abundant in skin, arterial walls, and heart valves, and may act to inhibit adenylate cyclase from rat hepatic membranes. Dermatan sulfate acts as a potent mediator of fibroblast growth factor-2 responsiveness.


Dermatan Sulfate (CAS 54328-33-5) References

  1. Structural and conformational aspects of the anticoagulant and anti-thrombotic activity of heparin and dermatan sulfate.  |  Casu, B., et al. 2004. Curr Pharm Des. 10: 939-49. PMID: 15078125
  2. Dermatan sulfate is the major metachromatic glycosaminoglycan in the integument of the anuran Bufo ictericus.  |  Pelli, AA., et al. 2007. Comp Biochem Physiol B Biochem Mol Biol. 146: 160-5. PMID: 17137817
  3. Antithrombin activity and disaccharide composition of dermatan sulfate from different bovine tissues.  |  Osborne, SA., et al. 2008. Glycobiology. 18: 225-34. PMID: 18156656
  4. Anticoagulant activity of a dermatan sulfate from the skin of the shark Scyliorhinus canicula.  |  Dhahri, M., et al. 2010. Blood Coagul Fibrinolysis. 21: 547-57. PMID: 20581662
  5. Modern developments in mass spectrometry of chondroitin and dermatan sulfate glycosaminoglycans.  |  Sisu, E., et al. 2011. Amino Acids. 41: 235-56. PMID: 20632047
  6. Chondroitin / dermatan sulfate modification enzymes in zebrafish development.  |  Habicher, J., et al. 2015. PLoS One. 10: e0121957. PMID: 25793894
  7. Photochemical depolymerisation of dermatan sulfate and analysis of the generated oligosaccharides.  |  Panagos, CG., et al. 2016. Carbohydr Polym. 140: 13-9. PMID: 26876822
  8. Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria.  |  Wang, S., et al. 2016. Glycoconj J. 33: 841-851. PMID: 27526113
  9. Purification and sequence characterization of chondroitin sulfate and dermatan sulfate from fishes.  |  Lin, N., et al. 2017. Glycoconj J. 34: 241-253. PMID: 28091940
  10. Recombinant dermatan sulfate is a potent activator of heparin cofactor II-dependent inhibition of thrombin.  |  Tykesson, E., et al. 2019. Glycobiology. 29: 446-451. PMID: 30869126
  11. Online preconcentration and determination of chondroitin sulfate, dermatan sulfate and hyaluronic acid in biological and cosmetic samples using capillary electrophoresis.  |  Chindaphan, K., et al. 2019. J Sep Sci. 42: 2867-2874. PMID: 31250530
  12. Structural basis of chemokine interactions with heparan sulfate, chondroitin sulfate, and dermatan sulfate.  |  Sepuru, KM. and Rajarathnam, K. 2019. J Biol Chem. 294: 15650-15661. PMID: 31455633
  13. Dermatan sulfate and chondroitin sulfate from Lophius litulon alleviate the allergy sensitized by major royal jelly protein 1.  |  Huang, X., et al. 2022. Food Funct. 13: 587-595. PMID: 34919100
  14. Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development.  |  Habicher, J., et al. 2022. PLoS Genet. 18: e1010067. PMID: 35192612
  15. Effects of Dermatan Sulfate from Marine Invertebrate Styela plicata in the Wound Healing Pathway: A Natural Resource Applied to Regenerative Therapy.  |  Rizzo-Valente, VS., et al. 2022. Mar Drugs. 20: PMID: 36354999

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dermatan Sulfate, 25 mg

sc-203916
25 mg
$1132.00

Dermatan Sulfate, 250 mg

sc-203916A
250 mg
$3070.00

Could you provide information about the source of this product?

Asked by: SSPL
Thank you for your question . The source is from plant (cockscomb).
Answered by: BlakeJ
Date published: 2024-04-03

I would like to know what is the sulphation pattern of this dermatan sulphate? I need a 2.6 or just 6 sulfated.

Asked by: Anonymous
Thank you for your question. Unfortunately, we do not have any information regarding this.
Answered by: BlakeJ
Date published: 2023-08-22

What is the molecular weight range of dermatan sulfate (mw: 30 kDa)?

Asked by: Sky_k
Thank you for your question. We only have the average: M.W. 30,000 (avg.).
Answered by: Technical Support
Date published: 2019-04-24

Hello. I work at VCU and would like to buy about 100mg of Dermatan Sulfate sc-203916. In your website I can see unit 250mg for this protein.Thank

Asked by: Quang Le
Thank you for your question. The smallest quantity that we can sell for this chemical is the advertised quantity of 250 mg.
Answered by: Technical Support
Date published: 2018-04-20
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Rated 5 out of 5 by from Godoy JA; et alGodoy JA; et al. (PubMed ID: 26349001) determined that Dermatan Sulfate in combination with endothelial progenitor cells increased the expression of adhesion molecules, prevented thrombosis, rescued the expression of eNOS in the vascular response to carotid artery lesion in C57BL6 mice. -SCBT Publication Review
Date published: 2015-03-20
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Dermatan Sulfate is rated 5.0 out of 5 by 1.
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