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AMPK Activator (CAS 849727-81-7)

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Synonym:5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942
Application:A cell-permeable AMP-activated protein kinase (AMPK) activator and survivin inhibitor
CAS Number:849727-81-7
Purity:>95%
Molecular Weight:368.4
Molecular Formula:C22H21FO4
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
AMPK Activator sc-203819 5 mg $225
Description
AMPK Activator is a furancarboxylic acid derivative that can permeate the cell and partially inhibit the mitochondrial complex I. Research shows that AMPK Activator increases glucose uptake in L6 myocytes, and inhibits CCL2-induced mTORC1 activity and survivin expression in human prostate cancer PC-3 cells (sc-2220). In multiple myeloma cells, AMPK Activator inhibits cell growth.
Technical Information
Physical State:Solid
Solubility:DMSO, methanol
Storage:Store at 4° C
Melting Point:134° C
Boiling Point:538.48 °C at 760 mmHg (Predicted)
Density:1.23 g/cm3 (Predicted)
Refractive Index:n20D 1.58 (Predicted)
IC50:glucose uptake: EC5050 = 11.7 µM (L6 myocytes)
Safety and Reference Information
PubChem CID:16760291
SMILES:C1=CC(=CC=C1CCCC2=CC=C(O2)C(=O)O)OCCC3=CC=C(C=C3)F
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Kosaka, T., et al. 2005. Anal. Chem. 77: 2050-2055. PMID: 1580173
2. Baumann, P., et al. 2007. Exp. Cell Res. 313: 3592-3603. PMID: 17669398
3. Roca, H., et al. 2009. Neoplasia. 11: 1309-1317. PMID: 20019839
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