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Phloxine B (CAS 18472-87-2)

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Synonym:Eosine I Bluish
Application:A phenyl-xanthene photoactive dye
CAS Number:18472-87-2
Molecular Weight:829.63
Molecular Formula:C20H2Br4Cl4Na2O5
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Phloxine B sc-203753 25 g $107
Phloxine B sc-203753A 100 g $200
Description
Phloxine B is a phenyl-xanthene dye which is known to inhibit the enzyme UDP-glucuronosyltransferase (UGT), the main catalyst for the glucuronidation of 7-HC. Additionally, Phloxine B is reported to be a poly(ADP-ribose) glycohydrolase (PARG) inhibitor. As a photoactive dye, Phloxine B is reported to have efficacy against gram-positive organisms. Phloxine B has also been utilized in a study investigating the visible light-induced photodegradation kinetics when coated onto silica TLC plates and in solution. The rapid photodegradation of Phloxine B via visible light exposure was noted and the phototoxicity of the remaining residues were also reported to be decreased.
Technical Information
Appearance:Powder
Physical State:Solid
Solubility:Soluble in water (1 mg/ml) (clear red solution).
Storage:Store at room temperature
Boiling Point:747.3 °C at 760 mmHg (Predicted)
pK Values:pKa: 1.32
Color Index Number:45410
Safety and Reference Information
WGK Germany:2
RTECS:LM5900000
PubChem CID:6433718
Merck Index:14: 10471
MDL Number:MFCD00070627
EC Number:242-355-6
Beilstein Registry:3887100
SMILES:[Na+].[Na+].[O-]C(=O)C1=C(C(Cl)=C(Cl)C(Cl)=C1Cl)C1=C2C=C(Br)C(=O)C(Br)=C2OC2 =C1C=C(Br)C([O-])=C2Br
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Slabbert, J.C., et al. 1990. J Esthet Dent. 2: 177-180. PMID: 2088435
2. Wang, H., et al. 2008. Biomed. Environ. Sci. 21: 438-441. PMID: 19133619
3. Brovko, L.Y., et al. 2009. J. Food Prot. 72: 1020-1024. PMID: 19517729
4. van Midwoud, P.M., et al. 2010. Anal. Chem. [Epub ahead of print]. PMID: 21128611
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