SSR 69071 (CAS 344930-95-6)
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SSR 69071 is a high affinity, potent inhibitor of Neutrophil Elastase (human leukocyte elastase, HLE) (IC50 = 3.9 nM) that displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). It inhibits human neutrophil elastase ex vivo in mouse bronchoalveolar lavage (BAL) fluid (ED50 = 10.5 mg/kg, p.o.). In vivo, SSR 69071 (2.8 mg/kg, p.o.) reduces acute lung hemorrhage induced by human neutrophil elastase in mice. It reduces carrageenan- and human neutrophil elastase-induced paw edema in rats (ED30s = 2.2 and 2.7 mg/kg, respectively). SSR 69071 also reduces cardiac infarct size when administered prior to ischemia or reperfusion in a rabbit model of ischemia-reperfusion injury.
SSR 69071 (CAS 344930-95-6) References
- SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury. | Bidouard, JP., et al. 2003. Eur J Pharmacol. 461: 49-52. PMID: 12568915
- Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor. | Kapui, Z., et al. 2003. J Pharmacol Exp Ther. 305: 451-9. PMID: 12606659
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SSR 69071, 10 mg | sc-203702 | 10 mg | $202.00 |