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Roxindole hydrochloride (CAS 112192-04-8)

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Application:A selective and potent presynaptic D-2 dopamine autoreceptor agonist
CAS Number:112192-04-8
Molecular Weight:382.93
Molecular Formula:C23H26N2O.HCl
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Roxindole hydrochloride sc-203685 10 mg $145
Roxindole hydrochloride sc-203685A 50 mg $615
Roxindole hydrochloride is a selective and potent presynaptic D2DR (D2 dopamine autoreceptor) agonist. Roxindole inhibits serotonin (5-HT) uptake.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (50 mM with gentle warming).
Storage:Store at -20° C
Boiling Point:575.7 °C at 760 mmHg (Predicted)
Density:1.17 g/cm3 (Predicted)
Refractive Index:n20D 1.65 (Predicted)
IC50:D2DR: EC5050 = 0.37 nM (human); SR-1A: IC50 = 0.8 nM (human); Serotonin 1a (5-HT1a) receptor: IC50 = 0.8 nM (rat); Dopamine D2 receptor: IC50 = 5.6 nM (rat)
Ki Data:D3DR: Ki= 0.4 nM (human); Dopamine D2 receptor: Ki= 0.88 nM (rat); D4DR: Ki= 24 nM (human); Dopamine D1 receptor: Ki= >10 µM (rat)
Safety and Reference Information
PubChem CID:9886286
MDL Number:MFCD04038810
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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1. Seyfried, C.A., et al. 1989. Eur. J. Pharmacol. 160: 31-41.
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