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Trichloroacetic acid (CAS 76-03-9)

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Synonym:TCA
Application:An acetic acid analogue commonly used to precipitate proteins, DNA and RNA
CAS Number:76-03-9
Purity:99%
Molecular Weight:163.39
Molecular Formula:C2HCl3O2
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Trichloroacetic acid sc-203414 250 g $50
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Description
Trichloroacetic acid is an acetic acid analogue commonly used to precipitate proteins, DNA and RNA. In the presence of SDS (sc-24950) Trichloroacetic acid will precipitate proteins which can then be quantified by the Lowry method. The compound has also found uses as a decalcifier and fixative in microscopy, in protein sequencing, detecting albumin and organic synthesis. Rats exposed to chronic sublethal amounts of trichloroacetic acid displayed an increase in serum bilirubin with a decrease in hematological proteins and cholesterols along with significant decreases in red blood corpuscles, mean cell volume, mean corpuscular hemoglobin, hemoglobin and hematocrit. In mice the production of liver tumors was associated to Trichloroacetic acid, which is also a known mouse hepatocarinogen. On the guinea pig trichloroacetic acid was observed to be a mild alergen on the skin.
Technical Information
Appearance:Colorless to white solid
Physical State:Solid
Solubility:Solubility: water
Storage:Store at 4° C
Safety and Reference Information
Transport:UN 1839, Class 8, Packing group II
PubChem CID:6421
SMILES:C(=O)(C(Cl)(Cl)Cl)O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Cabib, E. and Polacheck, I. 1984. Meth. Enzymol. 104: 415-416. PMID: 6717293
2. Chang, Y.C. 1992. Anal. Biochem. 205: 22-26. PMID: 1443557
3. Celik, I. and Temur, A. 2009. Food Chem. Toxicol. 47: 1324-1326. PMID: 19286448
4. Rajalingam, D., et al. 2009. Protein Sci. 18: 980-993. PMID: 19388015
5. Sweeney, L.M., et al. 2009. Toxicology. 260: 77-83. PMID: 19464572
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