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Thiostrepton (CAS 1393-48-2)

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Synonym:Bryamycin; Thiactin; Alaninamide
Application:A protein synthesis-inhibiting antibiotic
CAS Number:1393-48-2
Purity:≥95%
Molecular Weight:1664.88
Molecular Formula:C72H85N19O18S5
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Thiostrepton sc-203412 1 g $87
Thiostrepton sc-203412A 5 g $349
Description
Thiostrepton is a cyclic peptide antibiotic, densely packed with thiazoles and other structurally intriguing moieties. Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1.
Technical Information
Appearance:Powder
Physical State:Solid
Derived from:Streptomyces azureus
Solubility:Soluble in DMSO (10 mg/ml), chloroform (10 mg/ml), dioxane, pyridine, glacial acetic acid, and DMF. Insoluble in water.
Storage:Store at 4° C
Melting Point:246-256 °C
Density:1.64 g/cm3 (Predicted)
Refractive Index:n20D 1.77 (Predicted)
Safety and Reference Information
WGK Germany:3
RTECS:XN6300100
PubChem CID:16220061
Merck Index:14: 9364
MDL Number:MFCD00135828
EC Number:215-734-9
SMILES:CCC(C)[C@@H]1N[C@@H]2C=CC3=C(N=C(C=C3[C@H](C)O)C(=O)O[C@H](C)[C@@H]3NC(=O)C4 =CSC(=N4)[C@@H](NC(=O)[C@H]4CSC(=N4)C(NC(=O)[C@@H](NC(=O)C4=CSC(=N4)[C@]4(CC C(=N[C@H]4C4=CSC3=N4)C3=NC(=CS3)C(=O)NC(=C)C(=O)NC(=C)C(N)=O)NC(=O)[C@H](C)N C(=O)C(=C)NC(=O)[C@H](C)NC1=O)[C@@H](C)O)=C/C)[C@@](C)(O)[C@@H](C)O)[C@H]2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Bodley, J.W., et al. 1970. Biochem. Biophys. Res. Commun. 41: 1406-1411. PMID: 5487868
2. Kutay, U.R., et al. 1990. Biochim. Biophys. Acta. 1050: 193-196. PMID: 2169893
3. Smokvina, T., et al. 1990. Gene. 94: 53-59. PMID: 2227452
4. Thompson, J. and Cundliffe, E. 1991. Biochimie. 73: 1131-1135. PMID: 1720665
5. Ryan, P.C., et al. 1991. J. Mol. Biol. 221: 1257-1268. PMID: 1942050
6. Miller, S.P. and Bodley, J.W. 1991. Nucleic Acids Res. 19: 1657-1660. PMID: 2027773
7. Malina, H., et al. 1992. Appl. Environ. Microbiol. 58: 895-899. PMID: 1575490
8. Blanco, G., et al. 1992. Gene. 112: 59-65. PMID: 1551599
9. Saarma, U. and Remme, J. 1992. Nucleic Acids Res. 20: 3147-3152. PMID: 1377819
10. Rosendahl, G., et al. 1994. Nucleic Acids Res. 22: 357-363. PMID: 8127673
11. Chiu, M.L., et al. 1999. J. Biol. Chem. 274: 20578-20586. PMID: 10400688
12. Rodnina, M.V., et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 9586-9590. PMID: 10449736
13. Gonzalez, R.L., et al. 2007. RNA. 13: 2091-2097. PMID: 17951333
14. Kwok, J.M., et al. 2008. Mol. Cancer Ther. 7: 2022-2032. PMID: 18645012
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