Molecular structure of Sodium dichloroacetate, CAS Number: 2156-56-1
Sodium dichloroacetate (CAS 2156-56-1)
See product citations (6)
Alternate Names:
Dichloroacetic Acid Sodium Salt
Application:
Sodium dichloroacetate is an inhibitor of mitochondrial pyruvate dehydrogenase kinase
CAS Number:
2156-56-1
Purity:
≥99%
Molecular Weight:
150.92
Molecular Formula:
C2HCl2NaO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Sodium dichloroacetate may act to have numerous effects on pathways of intermediary metabolism. Experiments have reported the compound to inhibit gluconeogenesis and stimulate peripheral glucose utilization. It has additionally been found to facilitate oxidation of lactate via increase in activity of pyruvate dehydrogenase. This agent also demonstrates the ability to inhibit lipogenesis and cholesterolgenesis, as well as its own metabolism. Other studies suggest that sodium dichloroacetate inhibits tumor growth and may decrease proliferation and induce apoptosis in cancer cell lines. Sodium dichloroacetate is an inhibitor of PDK.
Sodium dichloroacetate (CAS 2156-56-1) References
- A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. | Bonnet, S., et al. 2007. Cancer Cell. 11: 37-51. PMID: 17222789
- The pharmacology of dichloroacetate. | Stacpoole, PW. 1989. Metabolism. 38: 1124-44. PMID: 2554095
- Why do some ME/CFS patients benefit from treatment with sodium dichloroacetate, but others do not? | Comhaire, F. 2018. Med Hypotheses. 120: 65-67. PMID: 30220343
- Pharmaceutical preformulation studies and paediatric oral formulations of sodium dichloroacetate. | Lopalco, A., et al. 2019. Eur J Pharm Sci. 127: 339-350. PMID: 30447284
- Sodium Dichloroacetate Pharmacological Effect as Related to Na-K-2Cl Cotransporter Inhibition in Rats. | Stanevičiūtė, J., et al. 2018. Dose Response. 16: 1559325818811522. PMID: 30479587
- Effect of sodium dichloroacetate on apoptotic gene expression in human leukemia cell lines. | Abramek, J., et al. 2019. Pharmacol Rep. 71: 248-256. PMID: 30822618
- Sodium Dichloroacetate Stimulates Angiogenesis by Improving Endothelial Precursor Cell Function in an AKT/GSK-3β/Nrf2 Dependent Pathway in Vascular Dementia Rats. | Zhao, H., et al. 2019. Front Pharmacol. 10: 523. PMID: 31156438
- Sodium dichloroacetate attenuates the growth of B16-F10 melanoma in vitro and in vivo: an opportunity for drug repurposing. | do Nascimento, RS., et al. 2021. Anticancer Drugs. 32: 111-116. PMID: 33395068
- Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses. | Joseph, S., et al. 2020. Drug Metab Dispos. 49: 451-458. PMID: 33811107
- Metformin and sodium dichloroacetate effects on proliferation, apoptosis, and metabolic activity tested alone and in combination in a canine prostate and a bladder cancer cell line. | Klose, K., et al. 2021. PLoS One. 16: e0257403. PMID: 34570803
- Impact of Sodium Dichloroacetate Alone and in Combination Therapies on Lung Tumor Growth and Metastasis. | Al-Azawi, A., et al. 2021. Int J Mol Sci. 22: PMID: 34830434
- Sodium dichloroacetate stimulates cardiac mitochondrial metabolism and improves cardiac conduction in the ovine fetus during labor. | Joseph, S., et al. 2022. Am J Physiol Regul Integr Comp Physiol. 322: R83-R98. PMID: 34851727
- Effects of supplementing low-protein diets with sodium dichloroacetate and glucose on growth performance, carcass traits, and meat quality of growing-finishing pigs. | Xu, Y., et al. 2022. J Anim Sci. 100: PMID: 34865045
- Clinical and radiologic improvements in mitochondrial encephalomyelopathy following sodium dichloroacetate therapy. | Kimura, S., et al. 1997. Brain Dev. 19: 535-40. PMID: 9440797
Inhibitor of:
AK2, BCKDE1A, BCKDHB, CARKL, CKMT1A, COASY, creatine kinase-B, GLYATL1, GLYCTK, GPT2, hnRNP E3, IDH3B, IDHC, LDH-C, LIAS, MCT4, NDUFA4L2, PDH-E1α, PDHA2, PDK, PDK1, PFK-1, PFKL, PGAM1, PGK1, PMPCB, RPUSD3, RyR-3, SCOCO, SCOT, SDHB, SDR-O, SIK1, SUCLG2, TKTL2, and XYLB.Activator of:
AK5, BCS1L, BRP44L, C20orf7, CHCHD4, CKMT1, CLYBL, COX4I2, HAO1, IDHC, LDH-AL6A, LDH-AL6B, LDHA, LDHC, LHPP, LOC283398, MCT3, MPV17L2, NDRG3, OGDHL, PDK3, PDPR, PHF7, PKM2, PTCD3, SLC25A18, SLC25A33, TLCD1, TMEM60, and USMG5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sodium dichloroacetate, 10 g | sc-203275 | 10 g | $54.00 | |||
Sodium dichloroacetate, 50 g | sc-203275A | 50 g | $205.00 |