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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of Abelson interacting protein 2 of human origin
- recommended for detection of Abelson interacting protein 2 and, to a lesser extent, Abelson interacting protein 1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-20326 P
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Ordering Information
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Abi-2 Background Information
The Abelson oncogene was initially identified as the viral transforming component of Abelson murine leukemia virus (A-MuLV). The Abelson gene (ABL1) encodes a SH2-domain bearing tyrosine kinase which conducts mitogenic signaling pursuant to growth factor receptor ligation. The Abl interactor proteins, Abi-1 and Abi-2, are SH3-domain containing proteins that bind to the proline-rich motifs of Abl and activate the kinase function. Two splice variants of Abi-1 are widely expressed, with the highest levels found in bone marrow, spleen, brain and testis. Abi-1 and Abi-2 are thought to negatively regulate cell growth and transformation, including cellular transformation through v-Abl. ABI1, the gene encoding Abi-1, has been shown to translocate and fuse with MLL (mixed lineage leukemia) gene in some cases of acute myeloid leukemia (AML). The Abi proteins have also been identified as mediators of cell motility by regulating Actin polymerization in lamellipodia and filopodia. |
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Abi-2 (A-20)
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Abi-2 (A-20): sc-20326. Western blot analysis of Abi-2 expression in 293T (A) and H69AR (B) whole cell lysates.
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