Potassium Phosphate, Dibasic, Anhydrous (CAS 7758-11-4)

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Application:	A reagent with very high buffering capacity widely used in molecular biology
CAS Number:	7758-11-4
Purity:	≥98%
Molecular Weight:	174.18
Molecular Formula:	K₂HPO₄

Ordering Information

Product Name	Catalog #	Unit	Price	Qty	Add
Potassium Phosphate, Dibasic, Anhydrous	sc-203210	500 g	$51
Potassium Phosphate, Dibasic, Anhydrous	sc-203210A	2 kg	$159

Description

Potassium Phosphate, Dibasic, Anhydrous (K2HPO4) is a reagent with a very high buffering capacity. Widely used in molecular biology, biochemistry, and chromatography. Potassium phosphate occurs in several forms: monobasic (KH2PO4), dibasic (K2HPO4), and tribasic (K3PO4). Neutral potassium phosphate buffer solutions may be prepared with a mixture of the monobasic and dibasic forms to varying degrees, depending on the desired pH. Potassium Phosphate buffers are very useful in numerous applications, but with the following limitations: precipitation of Ca²⁺ and Mg²⁺, inhibition of restriction enzyme activity, and interference in DNA ligation or bacterial transformation protocols. Has been used to study the effects of freezing and thawing on the stability of proteins sensitive to conformational changes; it was found that KP buffers offered improved pH stability as opposed to NaP buffers. Potassium Phosphate has also been used for the extraction of keratohyalin protein from bovine tissue.
Additional forms available:
Potassium Phosphate, Dibasic, Anhydrous (sc-203210)
Potassium Phosphate, Monobasic (sc-203211)
Potassium phosphate tribasic (sc-250766)
Potassium phosphate tribasic monohydrate (sc-250767)
Potassium phosphate dibasic solution (sc-301600)
Potassium Phosphate Monobasic solution (sc-301601)

Technical Information

Appearance:	White
Physical State:	Solid
Solubility:	Soluble in water (1600 g/l) at 20 °C, and ethanol (Slightly soluble).
Storage:	Store at room temperature
Melting Point:	340 °C
Boiling Point:	158 °C at 760 mmHg (Predicted)
Density:	2.3 g/cm³

Safety and Reference Information

WGK Germany:	3
RTECS:	TC5580000
PubChem CID:	24450
Merck Index:	14: 7658
MDL Number:	MFCD00011383
EC Number:	231-834-5
SMILES:	O.O.O.OP(=O)([O-])[O-].[K+].[K+]

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Ugel, A.R. and Idler, W. 1972. J. Cell Biol. 52: 453-464. PMID: 5057980
2. Pikal-Cleland, K.A., et al. 2000. Arch. Biochem. Biophys. 384: 398-406. PMID: 11368330
3. Sambrook, et al. 1989. Rnai: Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory Press. New York. Cold Spring Harbor. Vol. 3.

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