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- Specifications
- Offered as 10 mg (sc-203178)
- CAS Number: 109552-15-0
- Molecular Weight: 369.1
- Molecular Formula: C3H9NO7P2··2Na•5H2O
- Purity: ≥95%
- Physical Appearance: White solid.
- Solubility: soluble in H2O, Provided in hydrated form, contains five molecules of water.
- SMILES: C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].O.O.O.O.O.[Na+
].[Na+]
- Description
- Pamidronate, Disodium Salt is a bisphosphonate calcium metabolism regulator which specifically induces calcium reabsorption in bones. In addition, Pamidronate selectively activates γδTcells in peripheral blood mononuclear cells. Alternate studies indicate that Pamidronate, Disodium Salt promotes osteoblast proliferation and differentiation while inhibiting osteoclastogenesis and osteoclast function. Furthermore, Pamidronate down-regulates urokinase-type plasminogen activator expression by suppressing uPA mRNA in PC-3 cells.
- Storage
- For Research Use Only
- Reference Numbers
- PubChem Compound ID: 60342
- References
- 1. Kunzmann, V., et al. 1999. N. Engl. J. Med. 340: 737-738. PMID: 10068336
2. Iguchi, K., et al. 2007. Anticancer Res. 27: 3843-3848. PMID: 18225541
3. Panzavolta, S., et al. 2009. J. Inorg. Biochem. 103: 101-106. PMID: 18977031
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Pamidronate, Disodium Salt
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