Date published: 2026-7-13

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Meleagrin (CAS 71751-77-4)

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Application:
Meleagrin is an alkaloid displaying antineoplastic activity
CAS Number:
71751-77-4
Purity:
≥98%
Molecular Weight:
433.50
Molecular Formula:
C23H23N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Meleagrin is a natural product, specifically a secondary metabolite. This compound belongs to the family of roquefortine/meleagrin alkaloids, known for their diverse biological activities. Meleagrin has garnered interest in the field of research due to its potent biological properties, including antibacterial and antiviral activities. Its chemical structure enables it to interact with biological systems in unique ways, influencing various biochemical pathways.


Meleagrin (CAS 71751-77-4) References

  1. Production of mycotoxins on artificially and naturally infested building materials.  |  Nielsen, KF., et al. 1999. Mycopathologia. 145: 43-56. PMID: 10560628
  2. Cell cytotoxicity and mycotoxin and secondary metabolite production by common penicillia on cheese agar.  |  Larsen, TO., et al. 2002. J Agric Food Chem. 50: 6148-52. PMID: 12358494
  3. [The biosynthesis of low-molecular-weight nitrogen-containing secondary metabolite-alkaloids by the resident strains of Penicillium chrysogenum and Penicillium expansum isolated on the board of the Mir space station ].  |  Kozlovskiĭ, AG., et al. 2002. Mikrobiologiia. 71: 773-7. PMID: 12526198
  4. [Formation of alkaloids from Penicillium species fungi during growth on wheat kernels].  |  Vinokurova, NG., et al. 2003. Prikl Biokhim Mikrobiol. 39: 457-60. PMID: 14520967
  5. Roquefortine/oxaline biosynthesis pathway metabolites in Penicillium ser. Corymbifera: in planta production and implications for competitive fitness.  |  Overy, DP., et al. 2005. J Chem Ecol. 31: 2373-90. PMID: 16195849
  6. Alkaloids from a deep ocean sediment-derived fungus Penicillium sp. and their antitumor activities.  |  Du, L., et al. 2010. J Antibiot (Tokyo). 63: 165-70. PMID: 20186171
  7. A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum.  |  García-Estrada, C., et al. 2011. Chem Biol. 18: 1499-512. PMID: 22118684
  8. iTRAQ-based proteomic profiling of the barnacle Balanus amphitrite in response to the antifouling compound meleagrin.  |  Han, Z., et al. 2013. J Proteome Res. 12: 2090-100. PMID: 23540395
  9. Meleagrin, a new FabI inhibitor from Penicillium chryosogenum with at least one additional mode of action.  |  Zheng, CJ., et al. 2013. PLoS One. 8: e78922. PMID: 24312171
  10. The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.  |  Mady, MS., et al. 2016. Bioorg Med Chem. 24: 113-22. PMID: 26692349
  11. Covalent structure of a low-molecular-mass protein, meleagrin, present in a turkey (Meleagris gallopavo) ovomucoid preparation.  |  Odani, S., et al. 1989. J Biochem. 105: 660-3. PMID: 2760022
  12. Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway.  |  Newmister, SA., et al. 2018. Org Biomol Chem. 16: 6450-6459. PMID: 30141817
  13. Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies.  |  Hamed, A., et al. 2021. Nat Prod Res. 35: 3830-3838. PMID: 32189530
  14. Deletion of the Histone Deacetylase HdaA in Endophytic Fungus Penicillium chrysogenum Fes1701 Induces the Complex Response of Multiple Bioactive Secondary Metabolite Production and Relevant Gene Cluster Expression.  |  Ding, Z., et al. 2020. Molecules. 25: PMID: 32796640
  15. Meleagrin Isolated from the Red Sea Fungus Penicillium chrysogenum Protects against Bleomycin-Induced Pulmonary Fibrosis in Mice.  |  Elhady, SS., et al. 2022. Biomedicines. 10: PMID: 35625905

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Meleagrin, 1 mg

sc-203132
1 mg
$282.00

Meleagrin, 5 mg

sc-203132A
5 mg
$835.00

Meleagrin, 10 mg

sc-203132B
10 mg
$1501.00