Loperamide Hydrochloride (CAS 34552-83-5)

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Application:	A Ca²⁺ channel protein inhibitor and MOR activator
CAS Number:	34552-83-5
Purity:	≥99%
Molecular Weight:	513.51
Molecular Formula:	C₂₉H₃₃ClN₂O₂.HCl

This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

Description

Loperamide (Hydrochloride) is an opiate agonist with selectivity for the μ-opioid receptor. This specificity for μ-opioid receptors and limited penetrability into the brain prevent Loperamide from demonstrating central systemic effects generally associated with opiates, instead demonstrating localized action on the nociceptor and resultant antihyperalgesic action. Loperamide is shown to have an effect on the Ca²⁺ flux through high-voltage-activated calcium channels in response to high levels of extracellular K⁺, and at higher concentrations Loperamide is also a calcium channel protein inhibitor via the N-methyl-D-aspartate (NMDA) receptor-operated ion channel.

Technical Information

Appearance:	Yellow powder
Physical State:	Solid
Solubility:	Soluble in Methanol and Water: 16 g/100 ml
Storage:	Store at room temperature

Safety and Reference Information

Transport:	UN 3249, Class 6.1, Packing group III
PubChem CID:	71420
Merck Index:	14: 5571
MDL Number:	MFCD00058581
EC Number:	252-082-4
SMILES:	CN(C)C(=O)C(CCN1CCC(O)(CC1)C1=CC=C(Cl)C=C1)(C1=CC=CC=C1)C1=CC=CC=C1

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Awouters, F., et al. 1983. Annu. Rev. Pharmacol. Toxicol. 23: 279-301. PMID: 6307123
2. Church, J., et al. 1994. Mol. Pharmacol. 45: 747-757. PMID: 8183255
3. Daly, J.W., et al. 1995. Biochem. Pharmacol. 50: 1187-1197. PMID: 7488233
4. DeHaven-Hudkins, D.L., et al. 1999. J. Pharmacol. Exp. Ther. 289: 494-502. PMID: 10087042

SDS

Datasheet/SDS