Isofistularin-3 (CAS 87099-50-1)

Isofistularin-3, with the CAS number 87099-50-1, is a bioactive compound classified as a brominated indole alkaloid, predominantly derived from marine sponges of the genus Aplysina. This compound boasts a distinctive structure featuring a brominated indole core, which is key to its bioactivity. Isofistularin-3 operates through a mechanism that involves the inhibition of DNA methyltransferases (DNMTs), enzymes responsible for adding methyl groups to the DNA molecule, typically at cytosine bases in the context of CpG dinucleotides. This methylation is crucial for regulating gene expression and maintaining the integrity of the genome. By inhibiting DNMTs, isofistularin-3 can alter the methylation status of DNA, potentially leading to changes in gene expression patterns. In research, isofistularin-3 has been utilized as a tool to study epigenetic regulation and its implications in cellular processes. The ability of isofistularin-3 to modulate DNA methylation makes it especially valuable in studies focused on understanding the epigenetic mechanisms underlying cellular differentiation, development, and the maintenance of genomic stability. This compound′s unique properties and actions have also sparked interest in its potential as a reference compound in the development of novel epigenetic modulators, aiding in the exploration of epigenetic therapies and the biological effects of altered gene expression patterns.