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IBC 293 (CAS 306935-41-1)

Application:A selective GPR109b/HM74 receptor agonist
CAS Number:306935-41-1
Molecular Weight:205.2
Molecular Formula:C10H11N3O2
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
IBC 293 sc-203079 25 mg $200
IBC 293 is a cell permeable Niacin triazolo derivative that is a selective agonist towards the human orphan G-protein-coupled receptor GPR109b/HM74. In addition, IBC 293 inhibits forskolin (sc-3562) and isoproterenol (sc-202188) in GPR109b-expressing CHO cells and human adipocytes. The inhibition of forskolin and isoproterenol also causes a reduction in cAMP levels in both cell lines. It has been reported that GPR 109b occurs as homodimers and heterodimers in which the extent of homo-dimerization and hetero-dimerization does not depend on ligand binding.
Technical Information
Physical State:Solid
Solubility:DMSO or EtOH
Storage:Store at 4° C
Safety and Reference Information
PubChem CID:2736690
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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1. Mandrika, I., et al. 2010. Biochem. Biophys. Res. Commun. 395: 281-287. PMID: 20380810
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