Clobenpropit Dihydrobromide, VUF 9153 (CAS 145231-45-4)

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Application:	A histamine H3 receptor antagonist
CAS Number:	145231-45-4
Purity:	99%
Molecular Weight:	470.65
Molecular Formula:	C₁₄H₁₇ClN₄S 2HBr

Ordering Information

Product Name	Catalog #	Unit	Price	Qty	Add
Clobenpropit Dihydrobromide, VUF 9153	sc-202999	10 mg	$145
Clobenpropit Dihydrobromide, VUF 9153	sc-202999A	50 mg	$599

Description

Clobenpropit dihydrobromide, VUF 9153 has been shown to be an extremely potent (pA₂ = 9.93) and selective histamine H₃ receptor antagonist. This compound has been found to enhance the release of GABA, which protects against NMDA-induced exitotoxicity. Further experiments suggest that clobenpropit dihydrobromide my inhibit the binding of iodophenpropit, and therefor may possess the ability to cross the blood-brain barrier.

Technical Information

Appearance:	White
Physical State:	Solid
Solubility:	Readily Soluble in Water, DMSO and Ethanol.
Storage:	Store at 4° C

Safety and Reference Information

PubChem CID:	11213569
MDL Number:	MFCD00467655
SMILES:	C1=CC(=CC=C1CN=C(N)SCCCC2=CN=CN2)Cl.Br.Br

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Yokoyama, H., et al. 1994. Eur. J. Pharmacol. 260: 23-28. PMID: 7957622
2. Harada, C., et al. 2004. Brain Res. Bull. 63: 143-146. PMID: 15130703
3. Dai, H., et al. 2007. Eur. J. Pharmacol. 563: 117-123. PMID: 17350613
4. Devi, P.U., et al. 2010. Hum Exp Toxicol. [Epub ahead of print]. PMID: 20511290

SDS

Datasheet/SDS