Molecular structure of 1α,25-Dihydroxyvitamin D3, CAS Number: 32222-06-3
1α,25-Dihydroxyvitamin D3 (CAS 32222-06-3)
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Alternate Names:
1α,25-Dihydroxyvitamin D3 also known as Calcitriol; 1α,25-Dihydroxycholecalciferol; Topitriol; Soltriol; Vitamin D3, 1α,25-Dihydroxy-, Dihydroxycholecalciferol; Calcitriol-D6; 5- {2- [1- (5- Hydroxy- 1,5- dimethyl- hexyl)- 7a- methyl- octahydro- inden- 4- ylidene]- ethylidene}- 4- methylene- cyclohexane- 1,3- diol(1,25- Dihydroxyvitamin D3, Calcitriol); (1,25- Dihydroxyvitamin D3, Calcitriol)
Application:
1α,25-Dihydroxyvitamin D3 is also known as Calcitriol, the active form of vitamin D3, and an activator of PKC and VDR
CAS Number:
32222-06-3
Purity:
≥95%
Molecular Weight:
416.64
Molecular Formula:
C27H44O3
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1α,25-Dihydroxyvitamin D3, also known as Calcitriol, is a metabolite of the secosteroid vitamin D3. 1α,25-Dihydroxyvitamin D3 is a hormone that stimulates intestinal calcium transport at a much higher rate than vitamin D3 and hydroxy D3, and 1α,25-Dihydroxyvitamin D3 is considered to represent the biologically active form of vitamin D3. In addition to regulating the movement of calcium in the blood and bone, 1α,25-Dihydroxyvitamin D3 participates in developmental regulation and signaling. It stimulates an increase in protein kinase C levels with an effect on the regulation of c-myc transcription and activation of Raf kinase. 1α,25-Dihydroxyvitamin D3 is shown to increase the synthesis of prostacyclin with a correlated increase in cyclooxygenase activity, indicating a further role in vascular regulation. 1α,25-Dihydroxyvitamin D3 is an activator of PKC and VDR. 1α,25-Dihydroxyvitamin D3 has a widespread effect on cellular differentiation and proliferation, central nervous system function and can modulate immune responsiveness.
1α,25-Dihydroxyvitamin D3 (CAS 32222-06-3) References
- Vitamin D3 stimulates the production of prostacyclin by vascular smooth muscle cells. | Wakasugi, M., et al. 1991. Prostaglandins. 42: 127-36. PMID: 1775635
- Growth-inhibitory effects of 1,25-dihydroxyvitamin D3 on normal human keratinocytes cultured in serum-free medium. | Matsumoto, K., et al. 1990. Biochem Biophys Res Commun. 166: 916-23. PMID: 2405860
- 1,25-Dihydroxyvitamin D3 regulation of c-myc protooncogene transcription. Possible involvement of protein kinase C. | Simpson, RU., et al. 1989. J Biol Chem. 264: 19710-5. PMID: 2684961
- 1,25-Dihydroxyvitamin D3 and rat vascular smooth muscle cell growth. | Carthy, EP., et al. 1989. Hypertension. 13: 954-9. PMID: 2786849
- Synergistic potential of 1α,25-dihydroxyvitamin D3 and calcium-aluminate-chitosan scaffolds with dental pulp cells. | Bordini, EAF., et al. 2020. Clin Oral Investig. 24: 663-674. PMID: 31119382
- 1α,25-Dihydroxyvitamin D3-loaded hierarchical titanium scaffold enhanced early osseointegration. | He, P., et al. 2020. Mater Sci Eng C Mater Biol Appl. 109: 110551. PMID: 32228967
- 1α,25-Dihydroxyvitamin D3 ameliorates diabetes-induced bone loss by attenuating FoxO1-mediated autophagy. | Jiang, Y., et al. 2021. J Biol Chem. 296: 100287. PMID: 33450223
- 1α,25-Dihydroxyvitamin D3 Encapsulated in Nanoparticles Prevents Venous Neointimal Hyperplasia and Stenosis in Porcine Arteriovenous Fistulas. | Singh, AK., et al. 2021. J Am Soc Nephrol. 32: 866-885. PMID: 33627344
- 1α,25-dihydroxyvitamin D3 protects retinal ganglion cells in glaucomatous mice. | Lazzara, F., et al. 2021. J Neuroinflammation. 18: 206. PMID: 34530842
- Design, synthesis, and properties of des-D-ring interphenylene derivatives of 1α,25-Dihydroxyvitamin D3. | Ibe, K., et al. 2022. Eur J Med Chem. 243: 114795. PMID: 36244107
- 1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. | Mangelsdorf, DJ., et al. 1984. J Cell Biol. 98: 391-8. PMID: 6319426
- Direct activation of protein kinase C by 1 alpha,25-dihydroxyvitamin D3. | Slater, SJ., et al. 1995. J Biol Chem. 270: 6639-43. PMID: 7896803
- 1,25(OH)2-vitamin D3 signal transduction in chick myoblasts involves phosphatidylcholine hydrolysis. | de Boland, AR., et al. 1994. J Biol Chem. 269: 8675-9. PMID: 8132595
- Prediction of bone density from vitamin D receptor alleles. | Morrison, NA., et al. 1994. Nature. 367: 284-7. PMID: 8161378
- 1,25-Dihydroxyvitamin D3 activates Raf kinase and Raf perinuclear translocation via a protein kinase C-dependent pathway. | Lissoos, TW., et al. 1993. J Biol Chem. 268: 25132-8. PMID: 8227076
Inhibitor of:
β-defensin 2, Acnat2, AI314976, ANKH, C11orf93, CysLT1, CysRS, Ferroportin-1, HNF-3α, IgA chain C, LCE3E, LCE5A, LRRC17, Mucin, Nkx-3.1, NPT2, PHEX, RPLL26L1, Sclerostin, and SSTR2.Activator of:
α-defensin, α-defensin 1B, α-defensin 2, α-defensin 6, β-defensin 119, β-defensin 12, β-defensin 121, β-defensin 123, β-defensin 124, β-defensin 125, β-defensin 127, β-defensin 128, β-defensin 129, β-defensin 130, β-defensin 134, β-defensin 135, β-defensin 136, β-defensin 137, β-defensin 14, β-defensin 15, β-defensin 3, β-defensin 32, β-defensin 33, β-defensin 44, β-defensin 5, β-defensin 6, β-defensin 7, γ-parvin, γC-crystallin, 5133401N09Rik, AChR α 4, Ameloblastin, ANKRD2, AY026312, BC002199, Brk, C1orf172_1810019J16Rik, C20orf123, C2orf49_AI597479, C2orf73, C3, C330005M16Rik, CaBP7, Calbindin D28K, Calbindin D9K, Calgranulin A, Calgranulin B, CALHM2, CAP-18, CARD11, CARMIL, cathepsin 3, Cbl, CCL15, CD10, CD13, CD15, CD1A, CD209d, CD26, CD3-δ, CD33, CD35_Curry, CD46, CD62L ligand, CD68, Cdt1, Cdx2, CEACAM3, cementum attachment protein, CKR-5, cleaved-COL18A1, copine 4, cornulin, CS1, CX3CR1, CYP24, CYP27B1, Cytokeratin 10, Cytokeratin 2p, Cytokeratin 5, Cytokeratin 6, Cytokeratin 6D, Cytokeratin 6F, Cytokeratin 75, Cytokeratin 9, DGK-κ, Dmp1, DNA pol ε cat, dsg1α, dsg1β, EF-HB, EG436059, EG545948, EG574081, Epithelial Cytokeratin, FAM23A, FAM73B, FcRH1, Fcrl5, FGF-23, FHR-2, Filaggrin, G β1, GAL4 (DBD), GalNAc-T9, GATA-3, GFAP, GIPC2, Gm694, Granulocytee Marker, GRHL1, group X sPLA2, HGF, HNP, HoxD3, HR, HVEM, I830127L07Rik, ICSBP, Id2, IDH2, IFITM5, IgG2b, IGSF21, IL-10, IL-11Rα, IL-17F, IL-17RB, IL-20, IL-2Rβ, IL-4Rα, ILT-4, ILT-6, INPP5E, Integrin α4β7, Integrin VIb, INTS7, involucrin, ISX, Ivl, K230010J24Rik, KCP3, Keratin 17, Keratin 24, Keratin 25, Keratin 26, Keratin 28, Keratin 34, Keratin 39, Keratin 42, KIR3DL2, KIR3DL3, KIR3DS1, KLF17, KLK4, KLK8, KLKb5, KLRF1, KLRG1, KLRH1, KQT2, KRT222, KRTAP19, KRTAP9-L1, KRTDAP, Kua, L-type Ca++ CP α1C, LA-PF4, Lamin B2, Langerin, LCE1A, Lce1a2, LCE1D, LCE1E, LCE1F, Lce1h, Lce1k, LCE2B, LCE3C, LCE4A, LCE5A, LELP1, Lipocalin-3, Lipocalin-6, Lipocalin-8, Lipocalin-9, LMO2, LOC100039596, LOC100365008, LOC646567, LRIG1, LURAP1, Ly-6C2, Mac-3, Macoilin, Macrophagee Marker, MAdCAM-1, MADD, MCCD1, MCT6, MEPE, MGA, MGC33894, MHC class II I E, ML-IAP, MNDA, MPO, MRP-S14, MUP7, MYADML2, Myeloid Marker, MYH7, Myosin LC2, Mystique, N-type Ca++ CP α1B, Natural Killer Cell, neuromedin C, NFATc3, NIPA1, Nlk, NPT2, NRAMP 2, OAT2, OAT5, OC-2, Oculospanin, OG1, OG2, OLFML1, OPG, OPN, OR5H14, ORG, ORMDL2, OSCAR, osteocalcin, OSTF1, OTTMUSG00000002040, OTTMUSG00000002042, OTTMUSG00000002043, OTTMUSG00000002045, OTTMUSG00000006698, OTTMUSG00000011268, OTTMUSG00000016453, OTTMUSG00000017373, p63, Pax-2, PD-1, PEBP2β, PHM27, PHR1, PIG-Y, Pin1, Pira7, PiT1, PiT2, PITPα, PKC, Polycystin-L2, PR3, Presenilin 1, PRL-R, PTH-rP, PTH/PTHrP-R, RAI16, REG3α, REGIIIα, RelA, Repetin, resistin-like α, RGS6, RT1-Ac, RT1-Bα, S100A7A, SEEK1, SerpinB6e, Skp2 p45, SLC17A3, Sp3, SPAG11B, SPINK7, SPINK9, SPLUNC2, SPP24, SPRR2, SPRR2A, SPRR2B, SPRR2E, SPRR2F, Sprr3, SPRR4, SRCRB4D, Stap2, Stat6, STC1, suprabasin, T Cell, TEL, TMEM125, TMEM203, TNAP, TNF-R2, TRAC-1, TRAP, TRAP230, TREM-2a, TREM-2b, TRMP6, TRPC6, TRPS1, TRPV6, UCMA, UGRP2, USP17L2, VDR, VDUP1, VMAT 2, WFDC17, ZBTB40, and ZNF750.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1α,25-Dihydroxyvitamin D3, 50 µg | sc-202877B | 50 µg | $325.00 | |||
1α,25-Dihydroxyvitamin D3, 100 µg | sc-202877 | 100 µg | $400.00 | |||
1α,25-Dihydroxyvitamin D3, 1 mg | sc-202877A | 1 mg | $632.00 | |||
1α,25-Dihydroxyvitamin D3, 5 mg | sc-202877C | 5 mg | $1428.00 | |||
1α,25-Dihydroxyvitamin D3, 10 mg | sc-202877D | 10 mg | $2450.00 |