Welcome to Santa Cruz Biotechnology!

Thiocolchicine (CAS 2730-71-4)

(Based on popularity)

Synonym:10-Thio-colchicine
Application:A specific tubulin synthesis inhibitor and Topo I inhibitor
CAS Number:2730-71-4
Molecular Weight:415.5
Molecular Formula:C22H25NO5S
Refer to Certificate of Analysis for lot specific data (including water content).
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Thiocolchicine sc-202838 100 mg $210
Thiocolchicine sc-202838A 1 g $1,683
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Description
Thiocolchicine is an inhibitor of microtubules by specific binding to tubulin. Modulator of axonal cytoskeleton. Induces apoptosis. Topo I (topoisomerase I) inhibitor.
Technical Information
Physical State:Solid
Solubility:Soluble in 100% ethanol, DMSO, methanol, and chloroform. Almost insoluble in water.
Storage:Store at -20° C
Melting Point:154-158 °C
Boiling Point:729.06 °C at 760 mmHg (Predicted)
Density:1.28 g/cm3 (Predicted)
Refractive Index:n20D 1.61 (Predicted)
Optical Activity:α20/D -229.1º, c = 0.35 in chloroform
IC50:MDA-MB-231: IC50 = 0.6 nM (human); Human immunodeficiency virus 1: IC50 = 1.7 nM; L1210: IC50 = 8 nM (mouse); IGROV-1: IC50 = 12 nM (human); MCF7: IC50 = 0.4 µM (human)
Ki Data:Tubulin alpha chain: Ki= 0.7 µM (pig)
Safety and Reference Information
Transport:UN 1544, Class 6.1, Packing group I
RTECS:GH0878800
PubChem CID:17648
EC Number:220-346-8
SMILES:CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)OC
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
Association of thiocolchicine with tubulin: R.M. Chabin & S.B. Hastie; BBRC 161, 544 (1989) Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines: R. De Vincenzo, et al.; Anticancer Drug Des. 13, 19 (1998) Biological evaluation on different human cancer cell lines of novel colchicine analogs: R. De Vincenzo, et al.; Oncol. Res. 11, 145 (1999) Effects of thiocolchicine on axonal cytoskeleton of the rat peroneus nerve: P. Ferri, et al.; Exp. Toxicol. Pathol. 54, 211 (2002) Thiocolchicine dimers: a novel class of topoisomerase-I inhibitors: G. Raspaglio, et al.; Biochem. Pharmacol. 69, 113 (2005)
SDS (MSDS)
Certificate of Analysis

Catalog Number

Lot Number

Related Product Categories