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Thiocolchicine (CAS 2730-71-4)

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Application:A specific tubulin synthesis inhibitor and Topo I inhibitor
CAS Number:2730-71-4
Molecular Weight:415.5
Molecular Formula:C22H25NO5S
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Thiocolchicine sc-202838 100 mg $258
Thiocolchicine sc-202838A 1 g $1,683
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Thiocolchicine is an inhibitor of microtubules by specific binding to tubulin. Modulator of axonal cytoskeleton. Induces apoptosis. Topo I (topoisomerase I) inhibitor.
Technical Information
Physical State:Solid
Solubility:Soluble in 100% ethanol, DMSO, methanol, and chloroform. Almost insoluble in water.
Storage:Store at -20° C
Melting Point:154-158 °C
Boiling Point:729.06 °C at 760 mmHg (Predicted)
Density:1.28 g/cm3 (Predicted)
Refractive Index:n20D 1.61 (Predicted)
Optical Activity:α20/D -229.1º, c = 0.35 in chloroform
IC50:MDA-MB-231: IC50 = 0.6 nM (human); Human immunodeficiency virus 1: IC50 = 1.7 nM; L1210: IC50 = 8 nM (mouse); IGROV-1: IC50 = 12 nM (human); MCF7: IC50 = 0.4 µM (human)
Ki Data:Tubulin alpha chain: Ki= 0.7 µM (pig)
Safety and Reference Information
Transport:UN 1544, Class 6.1, Packing group I
PubChem CID:17648
EC Number:220-346-8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Association of thiocolchicine with tubulin: R.M. Chabin & S.B. Hastie; BBRC 161, 544 (1989) Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines: R. De Vincenzo, et al.; Anticancer Drug Des. 13, 19 (1998) Biological evaluation on different human cancer cell lines of novel colchicine analogs: R. De Vincenzo, et al.; Oncol. Res. 11, 145 (1999) Effects of thiocolchicine on axonal cytoskeleton of the rat peroneus nerve: P. Ferri, et al.; Exp. Toxicol. Pathol. 54, 211 (2002) Thiocolchicine dimers: a novel class of topoisomerase-I inhibitors: G. Raspaglio, et al.; Biochem. Pharmacol. 69, 113 (2005)
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