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Taurolidine (CAS 19388-87-5)

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Synonym:Taurolin; Tauroline
Application:An antibiotic
CAS Number:19388-87-5
Purity:≥98%
Molecular Weight:284.4
Molecular Formula:C7H16N4O4S2
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Taurolidine sc-202827 10 mg $45
Taurolidine sc-202827A 50 mg $165
Description
Taurolidine is a broad spectrum antibiotic that was derived from the aminosulfoacid Taurine (sc-202354). Shown to be effective against aerobic, anaerobic, gram-negative and gram-positive bacteria as well as fungi and mycobacterium. Found to exhibit antitumor activity with low toxicity, antiangiogenic effects, antiendotoxin activity, and to induce apoptosis of tumor cells; thereby decreasing proliferation of the tumor cells (both in vitro and in vivo). Has been used in studies of alternative chemotherapeutics, and is shown to work synergistically with rhTRAIL (sc-4547) doubling the effects of Taurolidine alone. The synergistic response of Taurolidine and TRAIL may outline a new therapeutic strategy in oncology therapy.
Additional Images
Taurolidine: sc-202827. Western blot analysis of ATF-3 expression in untreated (A) and Taurolidine treated (B) HT-1080 whole cell lysates. Note upregulation of ATF-3 expression in lane B. Antibody tested: ATF-3 (C-19): sc-188.
Technical Information
Physical State:Solid
Derived from:Synthetic
Solubility:Soluble in DMSO (>20 mg/ml), and water.
Storage:Store at -20° C
Melting Point:156 °C
Boiling Point:471.21 °C at 760 mmHg (Predicted)
Density:1.47 g/cm3 (Predicted)
Refractive Index:n20D 1.56 (Predicted)
pK Values:pKa: 11.16 (Predicted), pKb: 2.54 (Predicted)
Safety and Reference Information
WGK Germany:3
PubChem CID:29566
Merck Index:14: 9076
MDL Number:MFCD00865076
EC Number:243-016-5
SMILES:C1CS(=O)(=O)NCN1CN2CCS(=O)(=O)NC2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Watson, R.W., et al. 1995. J. Leukoc. Biol. 58: 299-306. PMID: 7665985
2. McCourt, M., et al. 2000. Ann. Surg. Oncol. 7: 685-691. PMID: 11034247
3. Calabresi, P., et al. 2001. Cancer Res. 61: 6816-6821. PMID: 11559556
4. Stendel, R., et al. 2009. Autophagy. 5: 194-210. PMID: 19066471
5. Jacobi, C.A., et al. 2005. Anticancer Drugs. 16: 917-921. PMID: 16162968
6. Bradshaw, J.H., et al. 2008. J. Pediatr. Gastroenterol. Nutr. 47: 179-186. PMID: 18664870
7. Daigeler, A., et al. 2008. Int. J. Oncol. 32: 1205-1220. PMID: 18497982
8. Chromik, A.M., et al. 2007. J Invest Surg. 20: 339-348. PMID: 18097875
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